microRNA在糖尿病心血管损伤中的作用和意义

被引:7
作者
汪燕燕 [1 ]
郑思道 [2 ]
于雯 [2 ]
机构
[1] 宁夏银川市中医医院糖尿病科
[2] 北京市中西医结合医院心内科
关键词
microRNA; 糖尿病; 心血管损伤; 心脏;
D O I
10.13621/j.1001-5949.2013.02.025
中图分类号
R587.1 [糖尿病];
学科分类号
100201 [内科学];
摘要
<正>糖尿病(DM)心血管损伤的主要表现为血管和心脏等结构和功能改变,涉及基因、蛋白等不同分子层次的多种机制。目前研究显示,表观遗传学机制在DM及其心血管并发症中具有重要作用,其中mi-croRNA(miRNA)介导的发病机制是目前研究的热
引用
收藏
页码:185 / 188
页数:4
相关论文
共 15 条
[1]
Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1 [J].
Meng, S. ;
Cao, J. -T. ;
Zhang, B. ;
Zhou, Q. ;
Shen, C. -X. ;
Wang, C. -Q. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 53 (01) :64-72
[2]
Pro-Inflammatory Role of MicroRNA-200 in Vascular Smooth Muscle Cells From Diabetic Mice [J].
Reddy, Marpadga A. ;
Jin, Wen ;
Villeneuve, Louisa ;
Wang, Mei ;
Lanting, Linda ;
Todorov, Ivan ;
Kato, Mitsuo ;
Natarajan, Rama .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (03) :721-U446
[3]
miR-146a-Mediated Extracellular Matrix Protein Production in Chronic Diabetes Complications [J].
Feng, Biao ;
Chen, Shali ;
McArthur, Kara ;
Wu, Yuexiu ;
Sen, Subhrojit ;
Ding, Qingming ;
Feldman, Ross D. ;
Chakrabarti, Subrata .
DIABETES, 2011, 60 (11) :2975-2984
[4]
MIR221/MIR222 -driven post-transcriptional regulation of P27KIP1 and P57KIP2 is crucial for high-glucose- and AGE-mediated vascular cell damage.[J].G. Togliatto;A. Trombetta;P. Dentelli;A. Rosso;M. F. Brizzi.Diabetologia.2011, 7
[5]
Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice [J].
Diao, Xuehong ;
Shen, E. ;
Wang, Xiaoxia ;
Hu, Bing .
MOLECULAR MEDICINE REPORTS, 2011, 4 (04) :633-640
[6]
MicroRNA-200b Regulates Vascular Endothelial Growth Factor-Mediated Alterations in Diabetic Retinopathy [J].
McArthur, Kara ;
Feng, Biao ;
Wu, Yuexiu ;
Chen, Shali ;
Chakrabarti, Subrata .
DIABETES, 2011, 60 (04) :1314-1323
[7]
Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia.[J]..Circulation.2011, 3
[8]
MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus [J].
Leeper, Nicholas J. ;
Cooke, John P. .
CIRCULATION, 2011, 123 (03) :236-238
[9]
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes [J].
Zampetaki, Anna ;
Kiechl, Stefan ;
Drozdov, Ignat ;
Willeit, Peter ;
Mayr, Ursula ;
Prokopi, Marianna ;
Mayr, Agnes ;
Weger, Siegfried ;
Oberhollenzer, Friedrich ;
Bonora, Enzo ;
Shah, Ajay ;
Willeit, Johann ;
Mayr, Manuel .
CIRCULATION RESEARCH, 2010, 107 (06) :810-U359
[10]
Individual microRNAs (miRNAs) display distinct mRNA targeting "rules" [J].
Wang, Wang-Xia ;
Wilfred, Bernard R. ;
Xie, Kevin ;
Jennings, Mary H. ;
Hu, Yanling ;
Stromberg, Arnold J. ;
Nelson, Peter T. .
RNA BIOLOGY, 2010, 7 (03) :373-380