肠道菌群对骨质疏松的影响机制及治疗的研究进展

被引：21

作者：

谢辉 ^{[1
,2
]}

林上阳 ^{[1
,2
]}

夏晨洁 ^{[1
,2
]}

吴丽 ^{[1
,3
]}

陈志鹏 ^{[1
,2
]}

李伟东 ^{[1
,2
]}

机构：

[1] 南京中医药大学药学院

[2] 南京中医药大学江苏省中药炮制重点实验室

[3] 南京中医药大学江苏省中药药效与安全性评价重点实验室

来源：

中国药理学通报 | 2020年 / 36卷 / 05期

关键词：

骨质疏松; 肠道菌群; 机制; 益生元; 中药; 治疗;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

肠道菌群是定植于人胃肠道内种类和数量繁多的微生物,与人类健康密切相关,现有大量研究发现肠道菌群与机体的骨骼健康密切相关。而肠道菌群影响骨质疏松的机制可能是通过自身代谢产物、影响宿主代谢、调节肠道屏障功能和免疫系统以及影响药物代谢等途径。对上述影响骨质疏松的机制进行探讨,并列举靶向肠道制剂治疗骨质疏松症的实例,为药物的作用机制研究提供新的途径,为解决各种原因引起的骨质疏松提供新的研究方向,为新药的研发提供新的思路。

引用

页码：600 / 603

页数：4

共 15 条

[1]

肠道菌—宿主代谢物组的分析平台的建立及应用 [D].

郑晓皎 .

上海交通大学,

2013

[2]

纳豆芽孢杆菌固体发酵低温豆粕的功能活性及机制研究 [D].

杨学娟 .

江苏大学,

2013

[3]

The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression [J].

Tyagi, Abdul Malik ;

Yu, Mingcan ;

Darby, Trevor M. ;

Vaccaro, Chiara ;

Li, Jau-Yi ;

Owens, Joshua A. ;

Hsu, Emory ;

Adams, Jonathan ;

Weitzmann, M. Neale ;

Jones, Rheinallt M. ;

Pacifici, Roberto .

IMMUNITY, 2018, 49 (06) :1116-+

[4]

High-throughput metabolomics investigates anti-osteoporosis activity of oleanolic acid via regulating metabolic networks using ultra-performance liquid chromatography coupled with mass spectrometry.[J].Yier Xu;Shuilin Chen;Tao Yu;Jiutao Qiao;Guicai Sun.Phytomedicine.2018,

[5]

Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats [J].

Levi, Yara L. A. S. ;

Novais, Gabriela S. ;

Dias, Raisa B. ;

Andraus, Rodrigo A. C. ;

Messora, Michel R. ;

Neto, Hermann B. ;

Ervolino, Edilson ;

Santinoni, Carolina S. ;

Maia, Luciana P. .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2018, 45 (09) :1078-1089

[6]

Mulberry and dandelion water extracts prevent alcohol-induced steatosis with alleviating gut microbiome dysbiosis [J].

Park, Sunmin ;

Kim, Da S. ;

Wu, Xuangao ;

Yi, Qiu J. .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 243 (11) :882-894

[7]

Enterolactone has stronger effects than enterodiol on ovarian cancer.[J].Huidi Liu;Jianrui Liu;Siwen Wang;Zheng Zeng;Ting Li;Yongfang Liu;Emilio Mastriani;Qing-Hai Li;Hong-Xia Bao;Yu-Jie Zhou;Xiaoyu Wang;Sijing Hu;Shan Gao;Yingying Qi;Zhihang Shen;Hongyue Wang;Miao Yu;Tingting Gao;Randal N. Johnston;Shu-Lin Liu.Journal of Ovarian Research.2017, 1

[8]

Dietary mannitol increased the absorption of calcium andmagnesium in rats [J].

Xiao, J. ;

Sakaguchi, E. ;

Min, X. ;

Kawasaki, K. .

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2016, 100 (04) :715-722

[9]

Flaxseed and its components differentially affect estrogen targets in pre-neoplastic hen ovaries.[J].Anushka Dikshit;Chunqi Gao;Carrie Small;Karen Hales;Dale Buchanan Hales.Journal of Steroid Biochemistry and Molecular Biology.2016,

[10]

Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes [J].

Xie, Guoxiang ;

Zhang, Shucha ;

Zheng, Xiaojiao ;

Jia, Wei .

ELECTROPHORESIS, 2013, 34 (19) :2787-2798

← 1 2 →