肠道稳态及相关疾病研究现状与趋势

被引:29
作者
刘小伟
孙瑞娟
董尔丹
机构
[1] 国家自然科学基金委员会医学科学部
关键词
D O I
暂无
中图分类号
R574 [肠疾病];
学科分类号
100201 [内科学];
摘要
<正>一、肠道稳态研究概况肠道稳态(gut homeostasis)是宿主(肠道黏膜和免疫屏障)、肠道内环境(包括肠道菌群)、营养和代谢产物等相互作用所构成的动态平衡状态,受到环境、生活方式、饮食习惯等多种因素影响。肠道黏膜屏障和免疫屏障一直是肠道稳态研究领域中的重点,受到研究者的持续关注,获得了诸多重要进展;而作为肠道内环境重要组成部分的肠道菌群(gutmicrobiota/gut microflora)则是近5年以来肠道稳态
引用
收藏
页码:206 / 212
页数:7
相关论文
共 9 条
[1]
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats [J].
Zhang, Hui-Lu ;
Yu, Le-Xing ;
Yang, Wen ;
Tang, Liang ;
Lin, Yan ;
Wu, Han ;
Zhai, Bo ;
Tan, Ye-Xiong ;
Shan, Lei ;
Liu, Qiong ;
Chen, Hai-Yang ;
Dai, Rong-Yang ;
Qiu, Bi-Jun ;
He, Ya-Qin ;
Wang, Chao ;
Zheng, Long-Yi ;
Li, Yu-Qiong ;
Wu, Fu-Quan ;
Li, Zhong ;
Yan, He-Xin ;
Wang, Hong-Yang .
JOURNAL OF HEPATOLOGY, 2012, 57 (04) :803-812
[2]
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 [J].
Dapito, Dianne H. ;
Mencin, Ali ;
Gwak, Geum-Youn ;
Pradere, Jean-Philippe ;
Jang, Myoung-Kuk ;
Mederacke, Ingmar ;
Caviglia, Jorge M. ;
Khiabanian, Hossein ;
Adeyemi, Adebowale ;
Bataller, Ramon ;
Lefkowitch, Jay H. ;
Bower, Maureen ;
Friedman, Richard ;
Sartor, R. Balfour ;
Rabadan, Raul ;
Schwabe, Robert F. .
CANCER CELL, 2012, 21 (04) :504-516
[3]
Honor Thy Gut Symbionts Redux [J].
Gordon, Jeffrey I. .
SCIENCE, 2012, 336 (6086) :1251-1253
[4]
Host-Gut Microbiota Metabolic Interactions [J].
Nicholson, Jeremy K. ;
Holmes, Elaine ;
Kinross, James ;
Burcelin, Remy ;
Gibson, Glenn ;
Jia, Wei ;
Pettersson, Sven .
SCIENCE, 2012, 336 (6086) :1262-1267
[5]
Interactions Between the Microbiota and the Immune System [J].
Hooper, Lora V. ;
Littman, Dan R. ;
Macpherson, Andrew J. .
SCIENCE, 2012, 336 (6086) :1268-1273
[6]
Obesity, Inflammatory Signaling, and Hepatocellular Carcinoma-An Enlarging Link [J].
Toffanin, Sara ;
Friedman, Scott L. ;
Llovet, Josep M. .
CANCER CELL, 2010, 17 (02) :115-117
[7]
Homeostasis and Inflammation in the Intestine [J].
Garrett, Wendy S. ;
Gordon, Jeffrey I. ;
Glimcher, Laurie H. .
CELL, 2010, 140 (06) :859-870
[8]
Inflammation and Intestinal Metaplasia of the Distal Esophagus Are Associated With Alterations in the Microbiome [J].
Yang, Liying ;
Lu, Xiaohua ;
Nossa, Carlos W. ;
Francois, Fritz ;
Peek, Richard M. ;
Pei, Zhiheng .
GASTROENTEROLOGY, 2009, 137 (02) :588-597
[9]
Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells [J].
Ma, Xiong ;
Hua, Jing ;
Li, Zhiping .
JOURNAL OF HEPATOLOGY, 2008, 49 (05) :821-830