B族维生素的镇痛和神经保护作用

被引：35

作者：

徐铌 ^{[1
,2
]}

宋学军 ^{[1
,2
]}

机构：

[1] 北京大学神经科学研究所

[2] 北京大学疼痛医学中心

来源：

中国疼痛医学杂志 | 2013年 / 19卷 / 10期

关键词：

B族维生素; 镇痛; 神经保护; 神经病理性疼痛;

D O I：

暂无

中图分类号：

R338 [神经生理学];

学科分类号：

100115 [医学神经生物学];

摘要：

B族维生素在生物代谢过程中扮演了重要的角色,人们逐渐发现其在镇痛方面的作用,临床上用以辅助治疗多种慢性疼痛,包括坐骨神经痛,三叉神经痛等。自2002年我们首先发现并连续报道了较大剂量的B族维生素(B1/B6/B12)可以通过调节感觉神经元异常钠离子通道的功能状态缓解神经病理性疼痛。我们的最新研究指出B族维生素在短暂性缺血引发的脊髓损伤的发生发展过程中不仅具有镇痛作用还有神经保护作用。

引用

页码：609 / 613

页数：5

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