细胞自噬与肿瘤

被引：67

作者：

杜海磊

邱伟华

杨卫平

机构：

[1] 上海交通大学附属瑞金医院外科,上海消化外科研究所

来源：

中国病理生理杂志 | 2010年 / 26卷 / 02期

关键词：

自吞噬作用; 细胞凋亡; 溶酶体; 肿瘤; 信号转导;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

Autophagy is a vacuolar process of cytoplasmic degradation by lysosome which ubiquitously occurring in all eukaryotic cells. The researches of autophagy have made great progress with the development of the yeast model and genetic technology. This review will summarize the determination of autophagy,its relationship with apoptosis and its role in the tumor treatment in order to give a comprehensive understanding of the function of autophagy.

引用

页码：401 / 404

页数：4

共 14 条

[1]

尘粒对巨噬细胞自噬的影响 [J].

王海杰 ;

谭玉珍 ;

何韬 ;

俞彰 .

中国病理生理杂志, 2008, (08) :1524-1528

[2]

自噬及自噬性细胞死亡抑制紫杉醇诱导的胃癌细胞凋亡 [J].

占贞贞 ;

陈思 ;

叶艳 ;

吴萍 ;

张旭东 ;

张林杰 .

安徽医科大学学报, 2007, (02) :123-127

[3]

自噬激活与抗肿瘤药物的作用 [J].

虞燕霞 ;

顾振纶 ;

秦正红 ;

梁中琴 .

中国药理学通报, 2006, (02) :137-141

[4]

Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells [J].

Li, Jie ;

Hou, Ni ;

Faried, Ahmad ;

Tsutsumi, Soichi ;

Takeuchi, Toshiyuki ;

Kuwano, Hiroyuki .

ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (03) :761-771

[5]

Autophagy revisited: A conversation with Christian de Duve.[J].Daniel J. Klionsky.Autophagy.2008, 6

[6]

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes [J].

Klionsky, Daniel J. ;

Abeliovich, Hagai ;

Agostinis, Patrizia ;

Agrawal, Devendra K. ;

Aliev, Giumrakch ;

Askew, David S. ;

Baba, Misuzu ;

Baehrecke, Eric H. ;

Bahr, Ben A. ;

Ballabio, Andrea ;

Bamber, Bruce A. ;

Bassham, Diane C. ;

Bergamini, Ettore ;

Bi, Xiaoning ;

Biard-Piechaczyk, Martine ;

Blum, Janice S. ;

Breclesen, Dale E. ;

Brodsky, Jeffrey L. ;

Brumell, John H. ;

Brunk, Ulf T. ;

Bursch, Wilfried ;

Camougrand, Nadine ;

Cebollero, Eduardo ;

Cecconi, Francesco ;

Chen, Yingyu ;

Chin, Lih-Shen ;

Choi, Augustine ;

Chu, Charleen T. ;

Chung, Jongkyeong ;

Clarke, Peter G. H. ;

Clark, Robert S. B. ;

Clarke, Steven G. ;

Clave, Corinne ;

Cleveland, John L. ;

Codogno, Patrice ;

Colombo, Maria I. ;

Coto-Montes, Ana ;

Cregg, James M. ;

Cuervo, Ana Maria ;

Debnath, Jayanta ;

Demarchi, Francesca ;

Dennis, Patrick B. ;

Dennis, Phillip A. ;

Deretic, Vojo ;

Devenish, Rodney J. ;

Di Sano, Federica ;

Dice, J. Fred ;

DiFiglia, Marian ;

Dinesh-Kumar, Savithramma ;

Distelhorst, Clark W. .

AUTOPHAGY, 2008, 4 (02) :151-175

[7]

Sequestration Revisited: Integrating Traditional Electron Microscopy; De Novo Assembly and New Results.[J].Attila L. Kovács;Zsolt Pálfia;Gábor Réz;Tibor Vellai;János Kovács.Autophagy.2007, 6

[8]

Cytosolic LC3 ratio as a sensitive index of macroautophagy in isolated rat hepatocytes and H4-II-E cells [J].