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两种水溶性卟啉与DNA相互作用的研究
被引：9
作者：
熊亚
黄素秋
吴鼎泉
屈松生
机构：
[1] 武汉大学化学系!武汉,武汉大学化学系!武汉,武汉大学化学系!武汉,武汉大学化学系!武汉
来源：
关键词：
卟啉;
DNA;
微量热法;
紫外光谱;
相互作用;
D O I：
暂无
中图分类号：
O626 [杂环化合物];
学科分类号：
070303 ;
081704 ;
摘要：
The interactions of two kinds of water-soluble porphyrins, Cu (NEAE) andH2PPS, with DNA have been investigated by microcajorimetry and UV spectroscopy.The experimental results show that Cu (NEAE) interact with dsDNA in the outside-boundmode, its binding number is 9～10 base pairs and its binding enthalpy △H＝-24．4kJ．mol-1.There are large enthalpy changes when Cu (NEAE) react with ssDNA. H2PPS can notreact with both dsDNA and ssDAN, which demonstrats that the coulombic force is one ofthe important factors affecting the interactions of porphyrins with DNA.
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页码：543 / 546
页数：4
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