基质金属蛋白酶-1在创伤性骨关节炎软骨及滑膜中的表达

被引：11

作者：

吴宏斌

杜靖远

郑启新

陈春莲

刘苏南

刘维钢

傅刚

机构：

[1] 华中科技大学同济医学院附属协和医院骨科

[2] 华中科技大学同济医学院附属同济医院病理科

[3] 华中科技大学同济医学院附属协和医院骨科武汉

[4] 武汉

来源：

中华创伤杂志 | 2003年 / 01期

关键词：

骨关节炎,创伤性; 前交叉韧带; 基质金属蛋白酶-1; 免疫组织化学;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

1002 ; 100210 ;

摘要：

目的　观察基质金属蛋白酶 - 1(MMP - 1)在兔前交叉韧带切断 (ACLT)创伤性骨关节炎 (OA)软骨及滑膜中的表达和分布 ,探讨MMP - 1表达与创伤性软骨退变之间的关系。　方法大耳白兔 2 0只行单侧ACLT术 ,术后 4周及 8周各处死 10只 ,另选 10只行单侧膝关节切开术作为假手术对照 ,于术后 8周处死。于解剖显微镜下行股骨关节面软骨退变大体评分 ,用免疫组化的方法检测MMP - 1在软骨及滑膜中的表达及分布。　结果　大体评分显示ACLT组软骨退变明显重于对照组 (P <0 .0 1) ,其中 8周组软骨退变程度又明显高于 4周组 (P <0 .0 5 )。MMP - 1主要在软骨表层及中上层、滑膜衬里层表达 ,其表达量随OA进展逐渐增高 (P <0 .0 5 )。OA早期 ,MMP - 1在滑膜中的增长滞后于它在软骨中的增长。　结论　MMP - 1与创伤性OA软骨退变关系密切 ,早期软骨退变主要源于软骨自身代谢改变 ,其后滑膜亦参与软骨退变。

引用

页码：41 / 45

页数：5

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