Th1/Th2细胞失衡在不稳定型心绞痛发病机制中的作用

被引：9

作者：

萨京

曾秋棠

王祥

郭和平

机构：

[1] 华中科技大学协和医院心内科

[2] 华中科技大学协和医院心内科华中科技大学同济医学院心血管病研究所武汉

[3] 华中科技大学同济医学院心血管病研究所武汉

来源：

临床心血管病杂志 | 2005年 / 10期

关键词：

心绞痛,不稳定型; 白细胞介素类; 辅助T细胞;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的:通过与超敏C反应蛋白(hsCRP)检测对比,探讨Th1相关的白细胞介素(IL)-12、IL-18和Th2相关的IL-10与不稳定型心绞痛的关系。方法:临床及冠状动脉造影确诊的50例不稳定型心绞痛患者作为病例组(男40例,女10例),30例非冠心病者作为对照组(男23例,女7例)。采用ELISA法检测血清中IL-10,IL-12及IL-18水平,乳胶增强免疫比浊法检测血清hsCRP水平。结果:病例组中,IL-12,IL-18水平增高,IL-10水平降低,均差异有统计学意义。对照组中上述指标没有显著改变。病例组中,hsCRP水平与IL-12,IL-18水平呈正相关,而与IL-10水平呈负相关。IL-12与IL-18水平呈正相关而两者均与IL-10水平呈负相关。结论:在不稳定型心绞痛患者的炎性反应中,Th2细胞活性降低,Th1细胞活性升高,导致了Th1/Th2的失衡。

引用

页码：588 / 590

页数：3

共 19 条

[1]

Macrophage infiltration in acute coronary syndromes.Implications for plaque rupture. Moreno P R,Falk E,Palacios I F,et al. Circulation . 1994

[2]

Immunohistochemical localization of C-reactive protein-binding sites in human atherosclerotic aortic lesions by a modified streptavidin-biotin-staining method. Hatanaka K,Li X A,Masuda K,et al. Pathology International . 1995

[3]

The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Davenport P,Tipping P G. American Journal of Pathology . 2003

[4]

Protective role of interleukin-10 in atherosclerosis. Mallat Z,Besnard S,Duriez M,et al. Circulation Research . 1999

[5]

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. van der Wal A C,Becker A E,van der Loos C M,et al. Circulation . 1994

[6]

IL-12 upregulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. Yoshimoto T,Takeda K,Tanaka T,et al. J Immunol . 1998

[7]

Interleukin-10 (IL-10 ) inhibits cytokine synthesis by human monocytes-an autoregulatory role of IL-10 produced by monocytes. de Waal Malefyt R,Abrams R J,Bennett B,et al. The Journal of Experimental Medicine . 1991

[8]

Molecular bases of the acute coronary syndromes. Libby P. Circulation . 1995

[9]

Immune mechanisms in atherosclerosis. Hansson G K. Arteriosclerosis and Thrombosis . 2001

[10]

Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Biasucci L M,Liuzzo G,Grillo R L,et al. Circulation . 1999

← 1 2 →