脑钠肽与原发性高血压左室重构相关性的临床研究

被引：4

作者：

罗少权 ^{[1
]}

王娟花 ^{[2
]}

机构：

[1] 湖南省隆回县人民医院

[2] 南华大学附属第一医院

来源：

现代生物医学进展 | 2010年 / 10卷 / 13期

关键词：

原发性高血压; 脑钠肽; 左室重量指数; 左室重构;

D O I：

10.13241/j.cnki.pmb.2010.13.023

中图分类号：

R544.1 [高血压];

学科分类号：

1002 ; 100201 ;

摘要：

目的:比较原发性高血压患者和健康对照个体血浆脑钠肽水平的差别,研究BNP同左室重量指数的关系,从而探讨BNP与高血压性心室重构的相关性。方法:收集我院2007年-2010年住院及门诊原发性高血压患者86例,以及健康体检者31例,均行血浆BNP,血清hs-CRP,总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),尿素氮(BUN),肌酐(CR),尿酸(UA)测定,同时行彩色多普勒超声心动图检查,记录室间隔厚度(IVST),左室后壁厚度(LVPWT),左室舒张末期内径(LVEDd),左室收缩末期内径(LVEDs),EF值,根据各项超声指标,计算出左室重量及左室重量指数LVMI=LVM/BSA。LVMI=LVM/BSA。所有研究对象分为EH组及健康对照组,86例EH患者按照血压水平的不同分为EH1,EH2,EH3等3组,按照是否合并有LVMI水平增高分为单纯EH组和EH合并LVH组。结果:①EH组较健康对照组BNP水平增高,差别有统计学意义(P=0.019,P<0.05)。②EH1,EH2,EH3组两两比较,EH3组较EH1组,EH2组BNP水平增高(P=0.026,0.029,P<0.05),EH1,EH2组之间差别无统计学意义(P>0.05)。③EH合并LVH组较单纯EH组BNP水平增高(P=0.036,P<0.05)。④随着血浆BNP水平的增高,LVMI增大,二者之间呈正相关关系(r=0.591,P<0.05);BNP与UA,LVEDd呈正相关关系(r=0.355,0.423,P均<0.05)。结论:高血压患者存在BNP水平的增高;BNP可反映高血压心室重构的程度。

引用

页码：2555 / 2557

页数：3

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