高同型半胱氨酸血症与缺血性脑血管病相关性

被引：9

作者：

潘晓华

高文伟

机构：

[1] 包头铁路医院

[2] 包头市电管局中心医院内蒙古包头

[3] 内蒙古包头

来源：

中国热带医学 | 2005年 / 08期

关键词：

同型半胱氨酸; 缺血性脑血管病; 危险因素;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑血管病的关系,并观察叶酸、维生素B6、维生素B12对Hcy的影响。方法对缺血性脑血管病患者123例(其中包括短暂性脑缺血发作47例,脑梗死76例)和正常对照组34例,采用高效液相色谱法测定空腹血浆Hcy浓度,并对高Hcy的58例患者进行叶酸、维生素B6、维生素B12治疗,2周后和6周后复查血浆Hcy浓度。结果①脑梗死及TIA组血浆Hcy浓度显著高于正常对照组(P<0.05);脑梗死组血浆Hcy浓度显著高于TIA组(P<0.01)。②缺血性脑血管病患者血脂水平与Hcy水平无明显相关。③缺血性脑血管病患者血浆Hcy水平和血压呈正相关(r=0.44,P<0.05)。④用叶酸、维生素B6、维生素B12治疗,6周后血浆Hcy水平有明显下降。结论高同型半胱氨酸血症是缺血性脑血管病的独立危险因素,遗传和维生素B6、维生素B12、叶酸缺乏可能是其增高的重要因素。

引用

页码：1679 / 1681

页数：3

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