肿瘤酸性微环境的形成机制及其对肿瘤进展的影响

被引：34

作者：

陈璐

高威

机构：

[1] 南京医科大学基础医学院细胞生物学系

来源：

肿瘤 | 2019年 / 39卷 / 02期

关键词：

肿瘤; 肿瘤微环境; 肿瘤逃逸; 膜转运蛋白质类; 肿瘤代谢;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

肿瘤微环境在肿瘤形成和发展中具有重要的作用,偏酸性是肿瘤微环境的显著特征之一。由于异常的血管结构以及肿瘤细胞的过度增殖,肿瘤组织通常处于缺氧状态,导致其代谢过程发生改变。相对于正常组织以有氧代谢为主的代谢过程,肿瘤组织的代谢则更多地依赖于无氧糖酵解,其代谢产物乳酸与呼吸作用产生的CO2共同造成了肿瘤微环境的酸化,并对肿瘤发生和发展的诸多方面产生影响。本文总结了肿瘤酸性微环境的形成机制,并从肿瘤免疫、侵袭转移、自噬和抗肿瘤治疗等方面阐述了偏酸性肿瘤微环境对肿瘤进展的影响和调控。

引用

收藏

页码：140 / 145

页数：6

相关论文

共 15 条

[1]

Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach.[J].Sophie Taylor;Enrico Pierluigi Spugnini;Yehuda G. Assaraf;Tommaso Azzarito;Cyril Rauch;Stefano Fais.Drug Resistance Updates.2015,

[2]

The contributions of respiration and glycolysis to extracellular acid production [J].

Mookerjee, Shona A. ;

Goncalves, Renata L. S. ;

Gerencser, Akos A. ;

Nicholls, David G. ;

Brand, Martin D. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2015, 1847 (02) :171-181

[3]

Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy [J].

Peppicelli, Silvia ;

Bianchini, Francesca ;

Calorini, Lido .

CANCER AND METASTASIS REVIEWS, 2014, 33 (2-3) :823-832

[4]

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress [J].

Marino, Maria Lucia ;

Pellegrini, Paola ;

Di Lernia, Giuseppe ;

Djavaheri-Mergny, Mojgan ;

Brnjic, Slavica ;

Zhang, Xiaonan ;

Hagg, Maria ;

Linder, Stig ;

Fais, Stefano ;

Codogno, Patrice ;

De Milito, Angelo .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (36) :30664-30676

[5]

Modulation of autophagic activity by extracellular pH [J].

Xu, Teng ;

Su, Hang ;

Ganapathy, Suthakar ;

Yuan, Zhi-Min .

AUTOPHAGY, 2011, 7 (11) :1316-1322

[6]

Proteolytic networks in cancer.[J].Steven D. Mason;Johanna A. Joyce.Trends in Cell Biology.2010, 4

[7]

Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia [J].

Ihnatko, Robert ;

Kubes, Miroslav ;

Takacova, Martina ;

Sedlakova, Olga ;

Sedlak, Jan ;

Pastorek, Jaromir ;

Kopacek, Juraj ;

Pastorekova, Silvia .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2006, 29 (04) :1025-1032

[8]

Does the tumor microenvironment influence radiation-induced apoptosis? [J].

Hunter, Alistair ;

Hendrikse, Andre ;

Renan, Michael ;

Abratt, Raymond .

APOPTOSIS, 2006, 11 (10) :1727-1735

[9]

Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs [J].

Thews, Oliver ;

Gassner, Birgit ;

Kelleher, Debra K. ;

Schwerdt, Gerald ;

Gekle, Michael .

NEOPLASIA, 2006, 8 (02) :143-152

[10]

Tumor acidity; chemoresistance and proton pump inhibitors.[J].Angelo De Milito;Stefano Fais.Future Oncol..2005, 6