胰岛素增敏剂治疗多囊卵巢综合征疗效与安全性

被引：4

作者：

付莹

卢实

李红发

机构：

[1] 华中科技大学同济医学院附属协和医院妇产科

来源：

国际妇产科学杂志 | 2010年 / 37卷 / 01期

关键词：

不孕症; 胰岛素抵抗; 二甲双胍; 多囊卵巢综合征; 噻唑烷二酮;

D O I：

暂无

中图分类号：

R711.75 [卵巢疾病];

学科分类号：

100211 [妇产科学];

摘要：

多囊卵巢综合征(PCOS)导致生殖和代谢功能紊乱的同时也增加罹患2型糖尿病及代谢综合征的危险。认识到胰岛素抵抗在PCOS发病中起到的作用后,以二甲双胍为代表的胰岛素增敏剂在临床广泛应用。最近一个以胎儿活产率(live-birth rate)为终点的随机对照试验(RCT)表明,单用二甲双胍治疗由PCOS引起的不孕症,其效果不及氯米芬。无证据证明应用二甲双胍能防止PCOS的妊娠妇女发生自然流产和妊娠期糖尿病。有研究噻唑烷二酮(TZD)类药物可能会增加心血管事件发生率。长期用药安全性的问题重新引起关注。

引用

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页码：47 / 49+71 +71

页数：4

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