氟伐他汀对自发性高血压大鼠阻力血管结构和功能的影响

被引：17

作者：

林志鸿

谢良地

吴可贵

王华军

许昌声

机构：

[1] 福建省高血压研究所福建医科大学附属第一医院!３５０００５福州市

[2] 福建省

来源：

中华心血管病杂志 | 1999年 / 01期

关键词：

降血脂药; 大鼠，近交SHR; 小动脉; 高血压;

D O I：

暂无

中图分类号：

R544.1 [高血压];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨氟伐他汀对自发性高血压大鼠（ＳＨＲ）阻力血管结构和功能的影响。方法ＳＨＲ大鼠出生后８周给予氟伐他汀２０ｍｇ·ｋｇ－１·ｄ－１。应用计算机图象分析，计算血管壁腔比，观察三组大鼠肠系膜动脉三级分支及主动脉结构变化。采用离体的主动脉和肠系膜动脉环对血管活性药物：去甲肾上腺素和硝普钠反应的敏感性，观察治疗后血管的功能变化。结果治疗８周后，氟伐他汀组（ＳＨＲｆｌｕ）收缩压比对照组（ＳＨＲ）平均低２１ｍｍＨｇ（１ｍｍＨｇ＝０．１３３ｋＰａ）（Ｐ＜０．０５）。ＳＨＲｆｌｕ肠系膜动脉三级分支比ＳＨＲ的血管壁薄，管腔大，血管的壁腔比显著小于未治疗的ＳＨＲ（Ｐ＜０．０５）。ＳＨＲｆｌｕ主动脉对硝普钠舒张的敏感性明显大于ＳＨＲ，其ＥＣ５０值远低于对照组（Ｐ＜０．０５）；肠系膜动脉对硝普钠舒张的敏感性略高于ＳＨＲ，ＥＣ５０是对照组的５６％。ＳＨＲｆｌｕ主动脉及肠系膜动脉对去甲肾上腺素收缩的敏感性均较ＳＨＲ明显减弱并达ＷＫＹ水平，ＥＣ５０显著提高（Ｐ＜０．０５）。结论短期氟伐他汀治疗，可以改善ＳＨＲ大鼠阻力血管的舒缩功能，使其对血管收缩物质的敏感性下降，对舒张物质的敏感性增加，同时也抑制了ＳＨＲ大鼠在高血压发展过程中伴随的血

引用

页码：56 / 60

页数：5

共 13 条

[1]

Atherosclerosis[P]. DONG CHUNMING;GOLDSCHMIDT PASCAL J.中国专利:US2008095751A1,2008-04-24

[2]

Inhibitory effects of fluvastatin, anew HMG-CoA reductase inhibitor, on the inerease in vascular ACEactivity in cholesterol-fed rabbits. Mitani H,Bandoh T,Ishikawa J,et al. British Journal of Pharmacology . 1996

[3]

Improvement ofmyocardial perfusion by short-term fluvastatin therapy in coronary arterydisease. Eichstaedt HW,Eskoetter H,Hoffmann I,et al. The American Journal of Cardiology . 1995

[4]

Protein isoprenylation and methylation at carboxyl-terminalcysteine residues. Clarke S. Annual Review of Biochemistry . 1992

[5]

Inhibitory effect of fluvastatinat doses insufficient to lower serum lipids on the catheter-inducedthickening of intima in rabbit remoral artery. Bandoh T,Mitani H,Niihashi M,et al. European Journal of Pharmacology . 1996

[6]

Involvement of rho P21 in theGTP-enhanced calcium ion sensitivity of smooth muscle contraction. Hirata K,Kikuchi A,Sasaki T,et al. Journal of Biological Chemistry . 1992

[7]

Pathogenesis of atherosclerosisand the role of 3-hydroxy-3-methylglutaryl coenzyme A wreductaseinhibitors. Corsini A,Raiteri M,Soma MR,et al. The American Journal of Cardiology . 1995

[8]

convention of restenosis aftercoronary balloon angioplasty: rationale and design of the FluvastatinAngioplasty Restenosis(FLARE) Trail.The FLARE Study Group. Foley DP,Bonnier H,Jackson G,et al. American Journal of Chinese Medicine . 1994

[9]

Is endothelial desfunction reversible. Schmieder RE,Schobel HP. American Journal of Chinese Medicine . 1995

[10]

Lovastatin prevents development of hypertension inspontaneously hypertensive rats. Jiang J,Richard J. Journal of Hypertension . 1997

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