补中益气汤对脾虚发热家兔体温、脑脊液PGE2和丘脑下部-视前区组织cAMP含量的影响

被引：5

作者：

张恩户

赵勤

侯建平

赵燕平

机构：

[1] 陕西中医学院药理教研室

来源：

中国中医基础医学杂志 | 2003年 / 08期

关键词：

补中益气汤; 甘温除热; 家兔脾虚发热模型;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

Objective:to research the antipyretic mechanisms of Buzhongyiqitang in reserpine induced splenasthenic rabbit.Method:The model of splenasthenic syndrome in rabbit was made by i.m.reserpine.Then,Buzhongyiqitang groups were given Buzhongyiqitang 5g/kg,10g/kg to stomach.On the 4 th day,observing the changes of temperature、PGE 2 in cerebrospinal fluid and cAMP in hypothalamus preoptic tissue between model group,control group and Buzhongyiqitang groups after i.v.TAB triple vaccine.Results:Buzhongyiqitang can remarkably reduce elevated temperature( P <0 01、 P <0 01),PGE 2 and cAMP.Conclusion:Buzhongyiqitang had antipyretic effect for reserpine induced splenasthenic syndrome with elevated temperature in rabbit.The mechanism is probably related to reducing PGE 2 and cAMP in concerned central nervous.

引用

页码：15 / 16

页数：2