重症抑郁障碍外周血microRNA的生物信息学分析

被引：4

作者：

范惠民 ^{[1
]}

吴文波 ^{[2
]}

牛威 ^{[3
]}

孙欣羊 ^{[1
]}

仲爱芳 ^{[4
]}

赵林 ^{[5
]}

张理义 ^{[6
]}

机构：

[1] 上海, 第二军医大学临床医学院精神卫生系

[2] 解放军医院急诊科

[3] 解放军医院康复科

[4] 解放军医院检验科

[5] 苏州市广济医院

[6] 解放军医院全军心理疾病防治中心

来源：

中华行为医学与脑科学杂志 | 2015年 / 24卷 / 05期

关键词：

miRNA; 重症抑郁障碍; 靶基因; 生物信息学;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

目的采用生物信息学方法预测has-miR-26b、has-miR-1972、has-miR-4485、has-miR-4498和has-miR-4743的靶基因, 并分析其所参与的生物学过程及信号通路, 为后续功能研究提供理论依据。方法应用TargetScan、miRBD及DIANA-microT-CDS预测上述5个miRNA的靶基因, 各个miRNA的预测结果分别取交集后, 再取其合集, 应用FunNet进行功能富集分析和信号通路富集分析。结果用3个在线数据库得到5个miRNA的靶基因的合集为734个;靶基因所涉及的生物学过程广泛, 包括多项与中枢神经系统相关的条目, 如皮层发育、轴突导向和延伸、突触传递以及学习和记忆过程等(P<0.05);所涉及的信号通路包括轴突导向、谷氨酸能突触、Wnt信号通路、ErbB信号通路、mTOR信号通路、VEGF信号通路等与重症抑郁障碍存在密切联系;has-miR-26b、has-miR-1972、has-miR-4498等3个miRNA在重症抑郁障碍中可能起着更加重要的作用。结论 has-miR-26b、has-miR-1972、has-miR-4485、has-miR-4498和has-miR-4743可能与重症抑郁障碍的发病机制密切相关。

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