急性胃肠炎与肠易激综合征发病风险相关性的Meta分析

被引:6
作者
张伟 [1 ]
吴晓亮 [2 ]
焦黛妍 [1 ]
陈璐 [2 ]
裴丽霞 [2 ]
孙建华 [2 ]
机构
[1] 南京中医药大学第二临床医学院
[2] 江苏省中医院针灸康复科
关键词
急性胃肠炎; 肠易激综合征; 系统评价; Meta分析; 队列研究;
D O I
暂无
中图分类号
R574.62 [结肠疾病];
学科分类号
100201 [内科学];
摘要
目的系统评价急性胃肠炎与肠易激综合征(IBS)发病的相关性。方法计算机检索h e Cochrane Library(2013年第8期)、PubMed、EMbase、Web of Science、CBM、CNKI、VIP和WanFang Data,收集急性胃肠炎与肠易激综合征发病风险相关性的前瞻性队列研究,检索时限均为从各数据库建库至2013年8月。由2位研究者按照纳入与排除标准独立筛选文献、提取资料并评价方法学质量后,采用RevMan 5.2软件进行Meta分析。结果共纳入11个队列研究,包括6?274例观察对象。根据不同的随访时间行亚组分析,Meta分析结果显示:与未感染的健康志愿者相比,急性胃肠炎患者在3个月、6个月、12个月、2~3年时,IBS发病风险增高[3个月:RR=6.46,95%CI(1.85,22.58),P=0.003;6个月:RR=4.68,95%CI(2.07,10.60),P=0.000?2;12个月:RR=4.95,95%CI(2.90,8.45),P<0.000?01;2~3年:RR=3.11,95%CI(2.72,3.56),P<0.000?01],但随访第5年,两组IBS发病风险无明显差异[RR=1.69,95%CI(0.68,4.24),P=0.26]。结论急性胃肠炎患者患病后3年内与IBS的发病具有一定相关性,其中性别、急性期腹泻持续天数、急性期脓血便和急性期腹部痉挛等因素可能是重要的诱发因素。在第5年时与IBS发病无相关性。鉴于纳入研究数量和样本量较少,上述结论尚需开展前瞻性研究进一步验证。
引用
收藏
页码:604 / 610
页数:7
相关论文
共 17 条
[1]
Prevalence of irritable bowel syndrome in Chinese college and university students assessed using Rome Ⅲ criteria[J] Yan-Yan Dong;Xiu-Li Zuo;Chang-Qing Li;Yan-Bo Yu;QiuJie Zhao;Yan-Qing Li;Department of Gastroenterology;Qilu Hospital;Shandong University;Jinan 250012;Shandong Province;China World Journal of Gastroenterology 2010,
[2]
Post-infectious irritable bowel syndrome[J] Marroon Thabane;John K Marshall; World Journal of Gastroenterology 2009,
[3]
The epidemiology of irritable bowel syndrome in Denmark. A population-based survey in adults ≤50 years of age[J] Laura Rindom Krogsgaard;Anne Line Engsbro;Peter Bytzer Scandinavian Journal of Gastroenterology 2013,
[4]
Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta‐analysis[J] M. Bashashati;N. Rezaei;H. Bashashati;A. Shafieyoun;N. E. Daryani;K. A. Sharkey;M. Storr Neurogastroenterology & Motility 2012,
[5]
Dyspepsia and irritable bowel syndrome in China: a population‐based endoscopy study of prevalence and impact[J] Y.Zhao;D.Zou;R.Wang;X.Ma;X.Yan;X.Man;L.Gao;J.Fang;H.Yan;X.Kang;P.Yin;Y.Hao;Q.Li;J.Dent;J.Sung;K.Halling;B.Wernersson;S.Johansson;J.He Alimentary Pharmacology & Therapeutics 2010,
[6]
Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J] Andreas Stang European Journal of Epidemiology 2010,
[7]
Postinfectious Irritable Bowel Syndrome[J] Robin Spiller;Klara Garsed Gastroenterology 2009,
[8]
Postinfectious Irritable Bowel Syndrome[J] Giovanni Barbara;Cesare Cremon;Francesca Pallotti;Roberto De Giorgio;Vincenzo Stanghellini;Roberto Corinaldesi Journal of Pediatric Gastroenterology and Nutrition 2009,
[9]
Postinfectious Irritable Bowel Syndrome After a Food-Borne Outbreak of Acute Gastroenteritis Attributed to a Viral Pathogen[J] John K. Marshall;Marroon Thabane;Mark R. Borgaonkar;Cindy James Clinical Gastroenterology and Hepatology 2007,
[10]
Postinfectious irritable bowel syndrome may occur after non‐gastrointestinal and intestinal infection[J] E. S.Mckeown;S. D.Parry;R.Stansfield;J. R.Barton;M. R.Welfare Neurogastroenterology & Motility 2006,