肠道菌群——治疗肥胖胰岛素抵抗的新靶点

被引：22

作者：

王雅媛

梁凤霞

黄琪

陈丽

机构：

[1] 湖北中医药大学针灸骨伤学院

来源：

华中科技大学学报(医学版) | 2019年 / 48卷 / 06期

关键词：

肠道菌群; 肥胖; 胰岛素抵抗; 能量代谢; 炎症; 肠-脑轴;

D O I：

暂无

中图分类号：

R589.2 [脂肪代谢障碍];

学科分类号：

100201 [内科学];

摘要：

<正>随着经济发展、生活方式以及环境的改变,肥胖人群日益庞大。世界卫生组织预计到2030年全球超重人口将突破21.6亿[1]。肥胖是由多种因素引起的机体能量代谢紊乱,会增加2型糖尿病、心血管疾病、脑卒中以及某些癌症的发病率和死亡率,故肥胖被认为是全球最大、增长最快的公共卫生问题。而胰岛素抵抗(insulin resistance,IR)是肥胖发展成2型糖尿病的关键病理基础,表现为脂肪组织、肝脏和骨骼肌等胰岛素靶器官对正常剂量的胰岛素敏感性不足

引用

页码：751 / 754+762 +762

页数：5

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