系统生物学在中药ADME性质研究中的应用

被引：9

作者：

杨凌

刘洪涛

马红

刘勇

郝大程

机构：

[1] 中国科学院大连化学物理研究所

来源：

世界科学技术-中医药现代化 | 2007年 / 01期

关键词：

系统生物学; ADME; 中药; PBPK模型;

D O I：

暂无

中图分类号：

R28 [中药学];

学科分类号：

1008 ;

摘要：

本文从中医的研究角度综述了系统生物学的定义、研究框架、范围和方法论特点,并以PBPK和PBPD研究为实例,详述了系统生物学方法论在药学研究中的最新应用和进展,阐明了系统生物学是还原论基础上的整体论。中医药是中医整体辩证理论指导下的复杂体系,拟乘系统生物学之势将面对诸多基础问题的挑战,然而中药ADME性质的阐明将成为中医药系统生物学研究的基石,从而将分子水平和整体水平有力地衔接起来。本文中同时简略地综述了作者研究组在该领域的有益尝试,结果表明中药的早期ADME性质研究方法将是揭开中药之谜并过渡到系统生物学水平的有力手段。

引用

页码：98 / 104

页数：7

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