山楂叶总黄酮对脑缺血-再灌注损伤的保护作用

被引：5

作者：

纪影实

李红

曲极冰

杨世杰

机构：

[1] 吉林大学白求恩医学院药理学教研室

来源：

中国老年学杂志 | 2009年 / 29卷 / 21期

关键词：

山楂叶总黄酮; 脑缺血-再灌注; 脑梗死;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的探讨山楂叶总黄酮(FMCL)对脑缺血-再灌注(CIR)损伤的保护作用及其可能机制。方法采用线栓法制备大鼠局灶性脑缺血-再灌注损伤模型,对其进行行为指标评分,TTC染色测定梗死范围,HE染色检测脑组织病理变化,透射电镜检测神经元超微结构变化,并检测大鼠脑组织匀浆中超氧化物歧化酶(SOD)活性、丙二醛(MDA)及一氧化氮(NO)含量的变化。结果FMCL可明显改善大鼠神经行为,缩小梗死范围,减轻脑组织病理改变,并可提高脑组织中SOD活性,降低脑组织中MDA及NO含量(P<0.05或P<0.01)。结论FMCL可减轻CIR神经细胞损伤,其机制可能与抗自由基损伤、减轻NO神经毒性有关。

引用

页码：2743 / 2746

页数：4

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