IKK激酶的NF-κB非相关性功能研究进展

被引：12

作者：

胡永亮 ^{[1
,2
]}

宋伦 ^{[1
]}

机构：

[1] 军事医学科学院基础医学研究所应激医学研究室

[2] 解放军第医院烧伤整形科

来源：

生物技术通讯 | 2015年 / 26卷 / 02期

关键词：

IKK复合物; NF-κB非相关性; IKKα; IKKβ;

D O I：

暂无

中图分类号：

Q55 [酶];

学科分类号：

070307 [化学生物学];

摘要：

IKK复合物由IKKα、IKKβ和IKKγ组成,是NF-κB通路中的重要分子,主要调控NF-κB通路的活化。近年的研究发现,IKK复合物还存在许多NF-κB非相关性的功能,主要涉及肿瘤发生、应激反应、转录调控、免疫功能及细胞周期调控等方面。IKK复合物的NF-κB非相关性的功能研究集中于IKKα和IKKβ亚基,并且存在激酶活性依赖和非依赖2种作用方式。对于该功能的深入探讨,对全面理解IKK分子的生理病理功能十分重要,并且为IKK分子的研究提出了一个新的方向。

引用

页码：268 / 271

页数：4

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