脓毒症相关性脑病的发病机制及治疗探讨

被引：20

作者：

王雪飞

李彬

刘清泉

郭玉红

机构：

[1] 首都医科大学附属北京中医医院

来源：

世界中医药 | 2014年 / 9卷 / 03期

关键词：

脓毒症; 脑病; 发病机制;

D O I：

暂无

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

脓毒症(spesis)是由感染引起的全身炎症反应综合征,脓毒症相关性脑病(Sepsis-Associated Encephalopathy,SAE)是脓毒症引起的弥漫性脑功能障碍,主要表现为精神状态和运动功能的改变,包括神智异常、昏迷、激动及活动减少等。近年来,脓毒症的研究不断深入,但脓毒症相关性脑病的研究和报道相对较少,目前该病发病机理尚不明确,诊断标准存在争论,治疗上主要直接针对脓毒症,对脑损伤尚无特效疗法,预后较差。深入研究脓毒症相关性脑病的发病机制,探讨该病的有效疗法将有助于提高患者生存质量,减轻家庭和社会的负担,提升危重疾病的临床诊疗水平。

引用

页码：281 / 284+287 +287

页数：5

共 16 条

[1]

白三烯受体拮抗剂ONO-1078对内皮素-1诱导的大鼠局灶性脑缺血的保护作用 [J].

张世红 ;

魏尔清 ;

朱朝阳 ;

陈忠 ;

张松法 .

药学学报, 2004, (01) :1-4

[2]

Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood–Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice [J].

Tsuyoshi Nishioku ;

Shinya Dohgu ;

Fuyuko Takata ;

Tomoaki Eto ;

Naoko Ishikawa ;

Kota B. Kodama ;

Shinsuke Nakagawa ;

Atsushi Yamauchi ;

Yasufumi Kataoka .

Cellular and Molecular Neurobiology, 2009, 29 :309-316

[3]

The encephalopathy in sepsis [J].

Siami, Shidasp ;

Annane, Djillah ;

Sharshar, Tarek .

CRITICAL CARE CLINICS, 2008, 24 (01) :67-+

[4]

Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model [J].

Semmler, Alexander ;

Frisch, Christian ;

Debeir, Thomas ;

Ramanathan, Mutiah ;

Okulla, Thorsten ;

Klockgether, Thomas ;

Heneka, Michael T. .

EXPERIMENTAL NEUROLOGY, 2007, 204 (02) :733-740

[5]

The cognitive consequences of critical illness: Practical recommendations for screening and assessment [J].

Gunther, Max L. ;

Jackson, James C. ;

Ely, E. Wesley .

CRITICAL CARE CLINICS, 2007, 23 (03) :491-+

[6]

Brain lesions in septic shock: a magnetic resonance imaging study [J].

Sharshar, Tarek ;

Carlier, Robert ;

Bernard, Francis ;

Guidoux, Celine ;

Brouland, Jean-Philippe ;

Nardi, Olivier ;

de la Grandmaison, Geoffroy Lorin ;

Aboab, Jerome ;

Gray, Francoise ;

Menon, David ;

Annane, Djillali .

INTENSIVE CARE MEDICINE, 2007, 33 (05) :798-806

[7]

The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion.[J].J. Althaus;M.D. Siegelin;F. Dehghani;L. Cilenti;A.S. Zervos;A. Rami.Neurochemistry International.2006, 1

[8]

Alterations of gene expressions of preproET-1 and ET receptors in brains of endotoxemic Sprague-Dawley rats [J].

Shimojo, Nobutake ;

Jesmin, Subrina ;

Zaedi, Sohel ;

Maeda, Seiji ;

Gando, Satoshi ;

Yamaguchi, Iwao ;

Goto, Katsutosih ;

Miyauchi, Takashi .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, 231 (06) :1058-1063

[9]

Oxidative variables, in the rat brain after sepsis induced by cecal ligation and perforation [J].

Barichello, T ;

Fortunato, JJ ;

Vitali, AM ;

Feier, G ;

Reinke, A ;

Moreira, JCF ;

Quevedo, J ;

Dal-Pizzol, F .

CRITICAL CARE MEDICINE, 2006, 34 (03) :886-889

[10]

Systemic inflammation induces apoptosis with variable vulnerability of different brain regions.[J].Alexander Semmler;Torsten Okulla;Magdalena Sastre;Lucia Dumitrescu-Ozimek;Michael T. Heneka.Journal of Chemical Neuroanatomy.2005, 2

← 1 2 →