药物性肝损伤的致病机制及影响因素

被引：16

作者：

滕光菊

孙颖

常彬霞

赵军

张伟

邹正升

李保森

机构：

[1] 解放军第医院非感染肝病科

来源：

肝脏 | 2011年 / 16卷 / 06期

关键词：

D O I：

10.14000/j.cnki.issn.1008-1704.2011.06.027

中图分类号：

R595.3 [药源性疾病];

学科分类号：

100201 [内科学];

摘要：

<正>药物性肝损伤(drug-induced liver injury,DILI)是指在治疗过程中由于药物的毒性损害或过敏反应所致的肝脏疾病,也称为药物性肝炎。肝脏是药物代谢、转化的主要脏器,也是机体代谢、免疫的重要器官,与药物关系密切。药物肝毒性的表现可从无症状、轻微、非特异性的生化改变到急性肝炎、慢性肝炎、急性肝衰、胆汁淤积,甚至肝硬化、肝脏肿瘤。目前,DILI已成为国内外常见且较严重的药源性疾病,并

引用

页码：497 / 500

页数：4

共 9 条

[1]

Causality Assessment in Drug-Induced Liver Injury Using a Structured Expert Opinion Process: Comparison to the Roussel-Uclaf Causality Assessment Method [J].

Rockey, Don C. ;

Seeff, Leonard B. ;

Rochon, James ;

Freston, James ;

Chalasani, Naga ;

Bonacini, Maurizio ;

Fontana, Robert J. ;

Hayashi, Paul H. .

HEPATOLOGY, 2010, 51 (06) :2117-2126

[2]

Glutathione S-transferase GSTT1 and GSTM1 allozymes:: beyond null alleles [J].

Agundez, Jose A. G. ;

Ladero, Jose M. .

PHARMACOGENOMICS, 2008, 9 (03) :359-363

[3]

Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury [J].

Lang, Carmen ;

Meier, Yvonne ;

Stieger, Bruno ;

Beuers, Ulrich ;

Lang, Thomas ;

Kerb, Reinhold ;

Kullak-Ublick, Gerd A. ;

Meier, Peter J. ;

Pauli-Magnus, Christiane .

PHARMACOGENETICS AND GENOMICS, 2007, 17 (01) :47-60

[4]

Role of innate immunity in acetaminophen-induced hepatotoxicity [J].

Liu, Zhang-Xu ;

Kaplowitz, Neil .

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2006, 2 (04) :493-503

[5]

Mechanisms of drug-induced liver injury [J].

Holt, MP ;

Ju, C .

AAPS JOURNAL, 2006, 8 (01) :E48-E54

[6]

Drug-Induced Hepatotoxicity: 2005.[J].Willis C Maddrey.Journal of Clinical Gastroenterology.2005, 4 Su

[7]

Mechanisms for Sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes [J].

Matsumaru, K ;

Ji, C ;

Kaplowitz, N .

HEPATOLOGY, 2003, 37 (06) :1425-1434

[8]

Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-α–induced apoptosis in cultured mouse hepatocytes.[J].Hidenari Nagai;Katsuhiko Matsumaru;Guoping Feng;Neil Kaplowitz.Hepatology.2002, 1

[9]

Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation..Deng X;Stachlewitz RF;Liguori MJ;Blomme EA;Waring JF;Luyendyk JP;Maddox JF;Ganey PE;Roth RA;.J Pharmacol Exp Ther.2006,

← 1 →