巨噬细胞在急性胰腺炎全身炎症反应中的作用

被引:11
作者
庄丹丹 [1 ]
欧希龙 [2 ]
机构
[1] 东南大学医学院
[2] 东南大学附属中大医院消化科
关键词
巨噬细胞; 胰腺炎; 全身炎症反应综合征; 炎症反应; 细胞因子; 文献综述;
D O I
暂无
中图分类号
R576 [胰腺疾病];
学科分类号
摘要
急性胰腺炎是一种严重的、可致全身多器官功能障碍的疾病,胰腺细胞及其他炎症细胞,如内皮细胞、粒细胞、淋巴细胞、单核-巨噬细胞能产生炎症介质,可引起全身炎症反应综合征。巨噬细胞在急性胰腺炎病理机制中可能起着至关重要的作用:腹腔巨噬细胞、肺泡巨噬细胞及肝脏枯否(kupffer)细胞在重症胰腺炎的不同阶段能被损伤的胰腺所释放的介质激活,进而释放大量细胞因子,触发炎症介质级联反应,引起全身炎症反应综合征。作者就巨噬细胞在急性胰腺炎全身炎症反应时对重要脏器的损害机制做一综述。
引用
收藏
页码:501 / 505
页数:5
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