丙泊酚对大鼠全心缺血-再灌注损伤后心肌细胞凋亡的影响

被引：3

作者：

周锦

张铁铮

王凤学

刘晓江

王朝仁

姚婧

王春丽

机构：

[1] 沈阳军区总医院麻醉科

来源：

临床麻醉学杂志 | 2003年 / 06期

关键词：

细胞凋亡; 丙泊酚; 心肌; 缺血-再灌注损伤;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

目的　探讨丙泊酚对大鼠全心缺血再灌注损伤后心肌细胞凋亡的影响。方法　Wis tar大鼠 36只 ,随机分为对照组 (C组 )和丙泊酚组 (P组 )。每组再分为缺血前、缺血 30min和再灌注30min三个亚组。采用DNA原位末端缺口标记技术 (TUNEL法 ) ,观察各组心肌细胞凋亡的变化情况。结果　与缺血前组相比较 ,缺血 30min及再灌注 30min各组的凋亡指数显著增加 (P <0 0 1) ,而丙泊酚组中缺血 30min及再灌注 30min各亚组的凋亡指数 ,均较对照组显著降低 (P <0 0 1)。结论　缺血 30min及再灌注 30min的心肌均发生了细胞凋亡 ,且再灌注组的细胞凋亡更为显著。丙泊酚可减少心肌缺血再灌注时心肌细胞凋亡的发生。

引用

页码：350 / 352

页数：3

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