过敏状态对肺炎支原体感染后血清白细胞介素-4、5及γ干扰素的影响

被引：3

作者：

冯金燕 ^{[1
]}

陈志敏 ^{[2
]}

机构：

[1] 浙江省慈溪市人民医院儿科

[2] 浙江大学附属儿童医院呼吸内科

来源：

中国小儿急救医学 | 2012年 / 03期

关键词：

肺炎支原体; 过敏; 细胞因子; 儿童;

D O I：

暂无

中图分类号：

R725.6 [小儿呼吸系及胸部疾病];

学科分类号：

摘要：

目的探讨宿主过敏状态对肺炎支原体(mycoplasma pneumoniae,MP)感染后血清白细胞介素(interleukin,IL)-4、IL-5及γ干扰素(interferon,IFN)-γ水平的影响及这些细胞因子水平与疾病严重度之间的关系。方法 95例MP感染患儿作为研究对象,分为过敏组与非过敏组、轻症组与重症组、高总IgE(TIgE)组与正常TIgE组。同时选取正常体检儿童38例作为正常对照组。应用ELISA法测定血清IL-4、IFN-γ和IL-5水平。结果 (1)MP感染组血清IL-4(pg/ml)、IFN-γ(pg/ml)和IL-5(pg/ml)水平[2.82(2.12,7.13),39.70(18.82,181.42),16.12(10.35,28.07)]均高于正常对照组[1.17(1.05,1.60),13.25(8.77,22.56),9.72(6.11,12.39)](P<0.05)。(2)MP感染过敏组、重症组及高TIgE组血清IL-5水平[15.55(10.35,22.61),15.98(11.95,26.58),16.55(10.35,23.65)]显著高于正常对照组(P<0.05),而非过敏组、轻症组及正常TIgE组血清IL-5水平与正常对照组比较差异无统计学意义(P>0.05)。(3)血清IL-4、IFN-γ水平及IL-4/IFN-γ比值在过敏组及非过敏组、轻症组与重症组及高TIgE组与正常TIgE组间比较差异均无统计学意义(P>0.05)。结论 IL-4、IFN-γ、IL-5参与了MP感染的发病机制,而且宿主本身的过敏体质会诱导血清IL-5水平升高,使病情向严重方向发展。

引用

页码：241 / 244

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