细胞程序性死亡与心肌再灌注损伤的研究进展

被引：8

作者：

刘丽凤

王禹

机构：

[1] 解放军总医院心内科

来源：

中华老年心脑血管病杂志 | 2015年 / 17卷 / 05期

关键词：

心肌再灌注损伤; 细胞死亡; 蛋白激酶类; 心肌梗死; 半胱氨酸天冬氨酸蛋白酶8; 肿瘤坏死因子α;

D O I：

暂无

中图分类号：

R542.2 [心肌疾病];

学科分类号：

1002 ; 100201 ;

摘要：

<正>心肌梗死、心力衰竭等心血管疾病发展过程涉及多种细胞死亡形式,包括坏死、凋亡及自噬等。既往认为坏死是被动的不受信号转导调控的过程,而目前研究认为至少有一部分坏死是受信号调节的,程序性坏死是一种依赖于受体相互作用蛋白激酶(RIPK)3的细胞死亡,这种死亡过程由特定的信号转导分子所驱动,其特点是形成以RIPK1和RIPK3为核心的坏死小体。程序性坏死参与调控心肌再灌注损伤

引用

页码：549 / 550

页数：2

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