多囊卵巢综合征患者非酒精性脂肪性肝病发病情况分析

被引：11

作者：

郑若姮

丁彩飞

机构：

[1] 浙江省中西医结合医院生殖医学科

来源：

中华妇产科杂志 | 2008年 / 02期

关键词：

多囊卵巢综合征; 脂肪肝; 胰岛素抵抗;

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

目的分析多囊卵巢综合征(PCOS)患者中非酒精性脂肪性肝病(NAFLD)的发病情况。方法选择 PCOS 患者60例为 PCOS 组、非 PCOS 患者60例为对照组,比较两组患者 NAFLD 的发病情况。结果 PCOS 组丙氨酸转氨酶(ALT)水平、空腹胰岛素水平和稳态模型胰岛素抵抗指数(HOMA-IR)分别为(29±15)U/L、(19±12)mU/L 和0.47±0.29,均显著高于对照组[分别为(15±13)U/L、(11±8)mU/L和0.31±0.21],差异均有统计学意义(P<0.05)。PCOS 组胰岛素抵抗、NAFLD 的发生率分别为63%(38/60)和42%(25/60),与对照组的35%(21/60)和20%(12/60)比较,差异有统计学意义(P<0.05)。PCOS 组 ALT 异常的发生率为40%(24/60),对照组为3%(2/60),两者比较,差异有统计学意义(P<0.01)。PCOS 组伴有 NAFLD 患者与不伴 NAFLD 患者比较,体重指数显著增高,差异有统计学意义(P<0.01);腰围臀围比值、ALT、C 反应蛋白、空腹胰岛素、口服葡萄糖耐量试验2h 后胰岛素水平和 HOMA-IR 也显著升高,差异也有统计学意义(P<0.05)。结论 PCOS 患者中 NAFLD 患病率升高,提示了两种疾病在临床上的相关性及对 PCOS 患者进行肝脏相关检查的必要性。

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