Caveolin-1蛋白与恶性肿瘤生长凋亡的研究进展

被引：6

作者：

郑亚民

齐保聚

李非

机构：

[1] 首都医科大学宣武医院普外科

来源：

现代肿瘤医学 | 2007年 / 09期

关键词：

caveolae结构; caveolin-1蛋白; 恶性肿瘤; 生长; 凋亡;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

Caveolae结构是细胞膜向内凹陷形成的囊状结构脂筏,caveolin蛋白是其标志蛋白。它们与囊泡转运、胆固醇稳态平衡、信号传导、肿瘤耐药、钙通道调控、细胞生长和凋亡等密切相关。Caveolin-1蛋白在不同肿瘤组织中表达变化具有两面性。本文介绍了Caveolae结构和Caveolin-1蛋白的特性和功能。重点综述了Caveolin-1蛋白对恶性肿瘤发生、生长和凋亡的作用。同时分析了一些当前新的认识和假说,并展望了caveolin-1在肿瘤治疗中的应用。

引用

页码：1355 / 1359

页数：5

共 8 条

[1]

Caveolin-1 inhibits anoikis and promotes survival signaling in cancer cells.[J].Dana Ravid;Sharon Maor;Haim Werner;Mordechai Liscovitch.Advances in Enzyme Regulation.2006, 1

[2]

Suppression of P-glycoprotein gene expression in Hs578T/Dox by the overexpression of caveolin-1 [J].

Zhu, H ;

Cai, CX ;

Chen, JW .

FEBS LETTERS, 2004, 576 (03) :369-374

[3]

Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation [J].

Capozza, F ;

Williams, TM ;

Schubert, W ;

McClain, S ;

Bouzahzah, B ;

Sotgia, F ;

Lisanti, MP .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (06) :2029-2039

[4]

Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung [J].

Yoo, SH ;

Park, YS ;

Kim, HR ;

Sung, SW ;

Kim, JH ;

Shim, YS ;

Lee, SD ;

Choi, YL ;

Kim, MK ;

Chung, DH .

LUNG CANCER, 2003, 42 (02) :195-202

[5]

Colocalization Prostacyclin (PGI2) Synthase–Caveolin-1 in Endothelial Cells and New Roles for PGI2 in Angiogenesis.[J].Enzo Spisni;Cristiana Griffoni;Spartaco Santi;Massimo Riccio;Roberta Marulli;Giovanna Bartolini;Mattia Toni;Volker Ullrich;Vittorio Tomasi.Experimental Cell Research.2001, 1

[6]

Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo [J].

Schnitzer, JE .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 49 (03) :265-280

[7]

Chromosomal localization; genomic organization; and developmental expression of the murine caveolin gene family (Cav-1; -2; and -3).[J].Jeffrey A. Engelman;Xiao Lan Zhang;Ferruccio Galbiati;Michael P. Lisanti.FEBS Letters.1998, 3

[8]

Caveolin-1在胃癌组织中的表达及临床生物学意义 [J].

高雪 ;

孙媛 ;

黄磊 ;

陈晓燕 ;

张开立 ;

孔庆友 ;

刘佳 ;

李宏 .

癌症, 2005, (03) :311-316

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