MicroRNA在微血管病变调控机制方面的研究进展

被引：2

作者：

朱振浩 ^{[1
]}

王明 ^{[2
]}

机构：

[1] 南方医科大学第二临床医学院

[2] 南方医科大学珠江医院中西医结合肾病中心

来源：

中国病理生理杂志 | 2013年 / 29卷 / 12期

基金：

广东省自然科学基金;

关键词：

微小RNA; 微血管病; 调控;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

<正>MicroRNA是新近发现的一种小分子RNA,参与了机体多种疾病的发生发展。近年研究发现,microRNA通过多种调控机制参与了微血管病变的发生发展。深入了解其调控机制不仅能够丰富人们对微血管病变的认识,对微血管病变的诊疗也具有重要的指导意义。现就microRNA在微血管病变发生发展中的调控机制予以概述。1 MicroRNA的概述MicroRNA(下文中带数字的microRNA用miR表示,如:miR-100)是一类内生的非编码小分子RNA,长约20～25个核苷酸,序列高度保守。编码microRNA的基因以多种形式存在于基因组中,包括单拷贝、多拷贝、基因簇等,其表达具有阶段特异性和组织特异性。MicroRNA基因转录后经过一系列加工处理才形成成熟的microRNA,包括了核内和核

引用

页码：2292 / 2296

页数：5

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