体外治疗性超声对人体凝血及纤溶系统的影响

被引：5

作者：

王海清

曹林生

蒋小燕

李运锋

机构：

[1] 浙江省人民医院心内科

[2] 华中科技大学同济医学院附属协和医院心血管研究所

[3] 华中科技大学同济医学院附属协和医院康复科

[4] 华中科技大学同济医学院附属协和医院心血管研究所杭州

来源：

中华物理医学与康复杂志 | 2004年 / 09期

关键词：

超声治疗; 血小板а-颗粒膜蛋白; 血栓烷B2; 组织型纤溶酶原激活剂; 纤溶酶原激活物抑制剂-1;

D O I：

暂无

中图分类号：

R454.3 [声疗法];

学科分类号：

100215 ;

摘要：

目的　研究体外治疗性超声 (ETUS)对正常人体凝血及纤溶系统的影响。方法　采用酶联免疫吸附法及发色底物法测定正常人经ETUS作用前、后 ,其血浆GMP 14 0、TXB2 、t PA及PAI 1含量的变化 ,并将经ETUS作用前、后的相应数据进行比较。结果　ETUS作用前 ,受试者GMP 14 0含量为 (3 .72± 0 .5 1)ng/ml ,TXB2 为 (87.64± 2 .62 )pg/ml ,t PA为 (0 .49± 0 .2 2 )IU/ml,PAI 1为 (0 .41± 0 .19)AU/ml ;经ETUS作用后 ,其GMP 14 0为 (3 .63± 0 .45 )ng/ml ,TXB2 为 (85 .84± 5 .18)pg/ml ,t PA为 (0 .46± 0 .0 2 )IU/ml,PAI 1为 (0 .3 6± 0 .15 )AU/ml ;经统计学分析 ,受试者经ETUS作用前、后各指标间差异均无显著性意义 (均P >0 .0 5 )。结论　本研究所用的治疗性剂量的ETUS对正常人体的凝血、纤溶系统没有明显影响

引用

页码：41 / 43

页数：3

共 11 条

[1]

Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots. Francis CW,Blinc A,Lee S,et al. Ultrasound in Medicine and Biology . 1995

[2]

Usefulness of laboratory techniques for evaluating antithrombotic efficacy of new therapeutic strategies. Amiral J. Clinical and Applied Thrombosis . 1995

[3]

Pro-and antifibrinolytic effects of ultrasound on streptokinase-induced thrombolysis. Nilsson AM,Odselius R,Roijer A,et al. Ultrasound in Medicine and Biology . 1995

[4]

Dose external ultrasound accelerate thrombolysis results from a rabbit model. Kornowski R,Meltzer RS,Chernine A,et al. Circulation . 1994

[5]

Characterization of ultrasound potentiated fibrinolysis in vitro. Blinc A,Frances CW,Trudnowski JL,et al. Blood . 1993

[6]

Transcutaneous ultrasound augments lysis of arterial thrombi in vivo. Luo H,Nishioka T,Fishbein MC,et al. Circulation . 1996

[7]

Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Tachibana K,Tachibana S. Circulation . 1995

[8]

Guidelines for the safe use of ultrasound therapy equipment. Safety of electrotherapy equipment working group. Physiotherapy . 1990

[9]

Ultrasound reversibly disaggregates fibrin fibers. Braaten JV,Goss RA,Francis CW,et al. Thrombosis and Haemostasis . 1997

[10]

Noninvasive, transthoracic, low-frequency ultrasound augments thrombolysis in a canine model of acute myocardial infarction. Siegel RJ,Atar S,Fishbein MC,et al. Circulation . 2000

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