基质金属蛋白酶11在喉癌中的表达

被引：7

作者：

段世宏

郭玉芬

机构：

[1] 兰州大学第二医院耳鼻咽喉头颈外科

来源：

临床耳鼻咽喉头颈外科杂志 | 2008年 / 03期

关键词：

喉肿瘤; 基质金属蛋白酶11; 肿瘤浸润; 肿瘤转移;

D O I：

暂无

中图分类号：

R739.6 [耳鼻咽喉肿瘤];

学科分类号：

摘要：

目的:检测喉癌中基质金属蛋白酶11(MMP11)的表达,探讨MMP11的表达与喉癌浸润和转移的关系。方法:采用免疫组织化学法检测63例喉癌组织和相应的癌旁正常组织MMP11蛋白的表达,运用RT-PCR技术检测22例喉癌和相应的癌旁正常组织冻存标本中MMP11 mRNA水平的表达。结果:采用免疫组织化学法检测喉癌和癌旁正常组织MMP11的表达,癌组织MMP11的表达阳性率明显高于癌旁正常组织(P<0.01)。运用RT-PCR方法检测喉癌和癌旁正常组织MMP11 mRNA的表达,癌组织MMP11 mRNA的表达阳性率明显高于癌旁正常组织(P<0.01)。MMP11蛋白表达在T3+T4组高于T1+T2组(P<0.01),淋巴结转移组高于非淋巴结转移组(P<0.05)。MMP11 mRNA表达在T3+T4组高于T1+T2组(P<0.05),淋巴结转移组高于非淋巴结转移组(P<0.05)。MMP11蛋白及MMP11 mRNA的表达与肿瘤原发部位和分化程度无明显相关性(P>0.05)。结论:MMP11的表达与喉癌浸润和转移密切相关,可作为预测喉癌浸润和转移潜能的参考指标之一。

引用

页码：104 / 107

页数：4

共 10 条

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