肌肉含量指标预测社区人群骨质疏松症风险研究

被引：8

作者：

杨秀琳 ^{[1
,2
]}

马斌 ^{[1
,2
]}

莫晓丹 ^{[1
,2
]}

马力扬 ^{[1
,2
]}

海向军 ^{[1
,2
]}

机构：

[1] 西北民族大学医学部

[2] 西北民族地区环境生态与人群健康国家民委重点实验室

来源：

中国骨质疏松杂志 | 2022年 / 28卷 / 02期

关键词：

肌肉量指标; 骨质疏松症; 风险; 预测;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

目的评价肌肉含量指标与骨质疏松症（osteoporosis, OP）的关联性,筛选预测社区人群OP风险的良好肌肉含量指标。方法选取来自甘肃省四个市、县的3 151名社区居民,用超声骨密度仪测量研究对象的骨强度、T值,运用生物电阻抗体成分分析仪分别测量四肢肌肉量,并计算四肢骨骼肌量（appendicular skeletal muscle mass, ASM）、四肢骨骼肌指数（appendicular skeletal muscle mass index, ASMI）、四肢骨骼肌体重比（skeletal muscle index, SMI）及四肢骨骼肌BMI比（ASM-to-BMI ratio）。应用ROC曲线及Logistic回归分析评价各肌肉量指标与OP风险的关联强度。结果男、女性ASM、ASMI、SMI、ASM-to-BMI ratio预测OP的ROC曲线下面积均有统计学意义（P<0.05）,最佳切点值:ASM:男19.550 kg,女16.350 kg; ASMI:男7.523 3 kg/m2,女6.463 3 kg/m2;SMI:男0.327 5,女0.281 6;ASM-to-BMI ratio:男0.898 6,女0.708 8。多因素Logistic回归分析显示,男性ASM与ASMI,女性ASM、ASMI与ASM-to-BMI ratio是预测OP风险有意义的肌肉量指标;男性ASM与AMSI均（+）组与均（-）组OP检出率分别为26.60%及4.38%;女性ASM、AMSI、ASM-to-BMI ratio均（-）组与均（+）组OP检出率分别为0.88%与23.78%。结论男性ASM与ASMI,女性ASM、ASMI与ASM-to-BMI ratio是预测OP风险的良好肌肉量指标;指标联合应用能显著提高预测OP风险的效果。

引用

页码：168 / 173

页数：6

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