骨性关节炎的发病机制及其与Wnt/β-catenin信号通路的关系

被引:5
作者
王哲彦 [1 ]
王文雅 [1 ]
张柳 [2 ]
机构
[1] 华北煤炭医学院病理教研室
[2] 华北煤炭医学院附属医院骨科
关键词
骨性关节炎; 软骨破坏; Wnt/β-catenin信号通路;
D O I
暂无
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
[目的]探讨Wnt/β-catenin信号通路在骨性关节炎发病过程中的重要作用。[方法]广泛查阅近年来有关骨性关节炎发病机制的国内外文献,并进行总结和分析。[结果]骨性关节炎的病变特征为软骨破坏和骨赘形成同时伴有滑膜的病变,近期研究证实Wnt/β-catenin信号通路在骨性关节炎发病中起着至关重要的作用。[结论]骨性关节炎是在诸多危险因素联合作用下的一种进行性病变,Wnt/β-catenin信号通路在骨性关节炎发病中起着至关重要的作用。
引用
收藏
页码:1800 / 1803
页数:4
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