沉默信息调节因子1信号通路在脑缺血—再灌注损伤中的保护作用

被引：10

作者：

谭凌菁

王金凤

梅志刚

机构：

[1] 三峡大学医学院国家中医药管理局中药药理科研三级实验室

来源：

中国脑血管病杂志 | 2016年 / 08期

关键词：

再灌注损伤; 炎性反应; 氧化性应激; 细胞凋亡; 沉默信息调节因子1; 综述;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

<正>沉默信息调节因子1(silent information regulator,SIRT1)是一种烟酰胺腺嘌呤二核苷酸依赖性组蛋白去乙酰化酶,可通过对各种组蛋白和非组蛋白的去乙酰化作用,调控炎性反应、氧化应激、细胞凋亡等多种病理过程和生命活动[1],对脑缺血-再灌注损伤起着重要的保护作用。本研究对SIRT1信号通路在脑缺血-再灌注损伤中的保护机制进行综述,为临床预防或治疗脑缺血-再灌注损伤寻求新靶点、开

引用

页码：442 / 445

页数：4

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