神经干细胞移植修复鼠脊髓损伤的实验研究

被引:4
作者
李立新
徐启武
车晓明
机构
[1] 复旦大学附属华山医院神经外科
关键词
神经干细胞; 脊髓损伤; 神经再生; 功能恢复;
D O I
暂无
中图分类号
R651.2 [脊髓];
学科分类号
1002 ; 100210 ;
摘要
目的 :观察神经干细胞移植治疗对鼠脊髓损伤后神经结构修复和功能恢复的作用并探讨其作用机制。方法 :制备鼠T10 脊髓损伤模型 ,体外培养、诱导鼠神经干细胞 ,定量评价神经干细胞移植对脊髓损伤后神经结构修复和功能恢复的影响。结果 :与对照组相比 ,神经干细胞移植组明显的增强了GAP 43mRNA的表达 ,促进了脊髓ChAT阳性的运动神经元的再生、结构的修复和下肢运动功能的恢复。结论 :神经干细胞移植促进了脊髓损伤后神经结构的修复和功能的恢复 ,是急性脊髓损伤一种有效的治疗方案
引用
收藏
页码:262 / 264+267 +267
页数:4
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