鼠脑缺血再灌注损伤后P-、L-选择素表达的研究

被引：2

作者：

张世明

孙雪波

机构：

[1] 苏州大学附属第一医院神经外科

来源：

中国临床神经科学 | 2003年 / 04期

关键词：

P-选择素; L-选择素; 脑缺血再灌注; 免疫组化;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的:探讨P-、L-选择素在鼠局灶性脑缺血再灌注损伤中的表达及作用。方法:72只雄性SD鼠分为假手术组和脑缺血2 h再灌注后2、3、4、6、12、24、48 h组,用线栓塞法建立脑缺血再灌注模型,免疫组化法检测缺血再灌注不同时间P-、L-选择素的表达。结果:P-选择素在缺血再灌注后3 h少量表达,12 h达高峰;L-选择素在脑缺血再灌注后2 h少量表达,6 h达高峰。结论:鼠局灶性脑缺血再灌注损伤中,P-、L-选择素明显上调,提示两者介导白细胞、微血管内皮细胞的粘附,参与脑缺血再灌注损伤的病理过程。

引用

页码：351 / 353+356 +356

页数：4

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