抑郁症大脑海马神经可塑性机制研究进展

被引:28
作者
孟盼 [1 ]
王宇红 [1 ,2 ,3 ]
张秀丽 [2 ]
机构
[1] 湖南中医药大学
[2] 湖南中医药大学第一附属医院
[3] 湖南省中药粉体与创新药物省部共建国家重点实验室培育基地
关键词
抑郁症; 神经递质; BDNF; CREB; 突触素; 海马可塑性;
D O I
10.13935/j.cnki.sjzx.2012.10.032
中图分类号
R749.4 [情感性精神病];
学科分类号
100204 [神经病学];
摘要
<正>抑郁症是以显著而持久的情绪低落或兴趣丧失为主要症状的一种精神疾病。关于抑郁症发病机制假说有以下几种:儿茶酚胺及受体假说;单胺假说;受体敏感假说;胆碱能—肾上腺素能功能平
引用
收藏
页码:914 / 917
页数:4
相关论文
共 15 条
[1]
抗抑郁症药物治疗靶标的研究进展 [J].
刘艳梅 ;
祁红 ;
陈红专 .
中国新药与临床杂志, 2005, (10) :764-768
[2]
BDNF对体外培养的大鼠脊髓前角神经元内突触素Ⅰ与突触囊泡素表达的影响 [J].
李昌琪 ;
刘丹 ;
卢大华 ;
罗学港 ;
鞠躬 .
神经解剖学杂志, 2005, (04) :340-344
[3]
苯甲酸雌二醇对去卵巢大鼠海马突触素和钙结合蛋白免疫活性的影响 [J].
刘凤华 ;
谭会兵 ;
左萍萍 ;
葛秦生 .
药学学报, 2000, (05) :339-342
[4]
Adult neurogenesis: integrating theories and separating functions [J].
Aimone, James B. ;
Deng, Wei ;
Gage, Fred H. .
TRENDS IN COGNITIVE SCIENCES, 2010, 14 (07) :325-337
[5]
Reduced right posterior hippocampal volume in women with recurrent familial pure depressive disorder [J].
Nifosi, Francesco ;
Toffanin, Tommaso ;
Follador, Halima ;
Zonta, Filippo ;
Padovan, Giordano ;
Pigato, Giorgio ;
Carollo, Carla ;
Ermani, Mario ;
Amista, Pietro ;
Perini, Giulia Ida .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2010, 184 (01) :23-28
[6]
Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation [J].
DeCarolis, Nathan A. ;
Eisch, Amelia J. .
NEUROPHARMACOLOGY, 2010, 58 (06) :884-893
[7]
Fluoxetine treatment induces dose dependent alterations in depression associated behavior and neural plasticity in female mice [J].
Hodes, Georgia E. ;
Hill-Smith, Tiffany E. ;
Lucki, Irwin .
NEUROSCIENCE LETTERS, 2010, 484 (01) :12-16
[8]
Increase in Hippocampal Volume After Electroconvulsive Therapy in Patients With Depression A Volumetric Magnetic Resonance Imaging Study [J].
Nordanskog, Pia ;
Dahlstrand, Ulf ;
Larsson, Magnus R. ;
Larsson, Elna-Marie ;
Knutsson, Linda ;
Johanson, Aki .
JOURNAL OF ECT, 2010, 26 (01) :62-67
[9]
Sustained stress-induced changes in mice as a model for chronic depression [J].
Elizalde, Natalia ;
Garcia-Garcia, Alvaro L. ;
Totterdell, Susan ;
Gendive, Nerea ;
Venzala, Elisabet ;
Ramirez, Maria J. ;
Del Rio, Joaquin ;
Tordera, Rosa M. .
PSYCHOPHARMACOLOGY, 2010, 210 (03) :393-406
[10]
Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats [J].
Marais, Lelanie ;
Stein, Dan J. ;
Daniels, Willie M. U. .
METABOLIC BRAIN DISEASE, 2009, 24 (04) :587-597