抑郁症未用药患者唾液皮质醇觉醒反应与自杀意念的关系

被引：7

作者：

吴岚村

伍绪忠

机构：

[1] 湖北省襄阳市安定医院

来源：

临床精神医学杂志 | 2017年 / 27卷 / 03期

关键词：

抑郁症; 自杀意念; 皮质醇觉醒反应;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

目的:探讨抑郁症未用药患者的自杀意念与唾液皮质醇觉醒反应(CAR)的关系。方法:对30例未服药的抑郁症患者(抑郁症组)及30名健康志愿者(健康对照组)进行自杀意念自评量表(SIOSS)评估及早晨觉醒后0、30、45及60 min时的唾液皮质醇水平检测;分析影响SIOSS评分的相关因素。结果:抑郁症组SIOSS总分及各因子评分(P均<0.01)、觉醒后0、30、45 min时唾液皮质醇浓度及CAR曲线下面积(AUCg)显著高于健康对照组(t=2.892,t=3.209,t=2.350,t=3.418;P<0.05或P<0.01);以年龄、性别、体质量指数、睡眠时间以及觉醒时间作为协变量分析发现,其对皮质醇浓度既无主效应也无交互作用。结论:抑郁症患者存在较强的自杀意念及CAR水平显著升高;CAR可能是预测抑郁症患者自杀意念强度的生物学指标。

引用

页码：175 / 177

页数：3

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