肠道菌群及胆汁酸在代谢性疾病的作用

被引：22

作者：

罗茜

聂启兴

姜长涛

机构：

[1] 北京大学基础医学院生理学与病理生理学系分子心血管学教育部重点实验室

来源：

生理科学进展 | 2022年 / 53卷 / 06期

关键词：

肠道菌群; 胆汁酸; 代谢性疾病; 胆汁酸受体; 代谢;

D O I：

10.20059/j.cnki.pps.2022.11.1105

中图分类号：

R589 [代谢病];

学科分类号：

100201 [内科学];

摘要：

肠道菌群(gut microbiota)在多种代谢性疾病的发生发展中发挥着重要的作用，包括肥胖、2型糖尿病、非酒精性脂肪性肝病、心血管疾病等。肠道菌群可以将肝脏中合成并被分泌到肠道中的胆汁酸(bile acids)进一步代谢，形成次级胆汁酸。多种胆汁酸按不同的比例构成胆汁酸池，并通过胆汁酸受体法尼醇X受体、G蛋白偶联胆汁酸受体等作用于宿主，进而影响宿主代谢。本文就肠道菌群代谢胆汁酸以及动态的肠道菌群和胆汁酸池调节代谢性疾病进展的机制进行综述。

引用

页码：409 / 415

页数：7

共 38 条

[1]

Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters.[J].Lulu Sun;Yuanyuan Pang;Xuemei Wang;Qing Wu;Huiying Liu;Bo Liu;George Liu;Min Ye;Wei Kong;Changtao Jiang;.Acta Pharmaceutica Sinica B.2019, 04

[2]

Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis [J].

Wu, Qing ;

Liang, Xianyi ;

Wang, Kai ;

Lin, Jun ;

Wang, Xuemei ;

Wang, Pengcheng ;

Zhang, Yangming ;

Nie, Qixing ;

Liu, Huiying ;

Zhang, Zhipeng ;

Liu, Junhui ;

Pang, Yanli ;

Jiang, Changtao .

CELL METABOLISM, 2021, 33 (10) :1988-+

[3]

Review: microbial transformations of human bile acids [J].

Guzior, Douglas V. ;

Quinn, Robert A. .

MICROBIOME, 2021, 9 (01)

[4]

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer [J].

Sun, Lulu ;

Cai, Jie ;

Gonzalez, Frank J. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2021, 18 (05) :335-347

[5]

Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.[J].Zheng Xiaojiao;Chen Tianlu;Jiang Runqiu;Zhao Aihua;Wu Qing;Kuang Junliang;Sun Dongnan;Ren Zhenxing;Li Mengci;Zhao Mingliang;Wang Shouli;Bao Yuqian;Li Huating;Hu Cheng;Dong Bing;Li Defa;Wu Jiayu;Xia Jialin;Jia Wei.Cell Metabolism.2020, 4

[6]

Gut microbiota-derived metabolites as central regulators in metabolic disorders.[J].Agus Allison;Clément Karine;Sokol Harry.Gut.2020, 6

[7]

Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health [J].

Jia, Baolei ;

Park, Dongbin ;

Hahn, Yoonsoo ;

Jeon, Che Ok .

GUT MICROBES, 2020, 11 (05) :1300-1313

[8]

Global chemical effects of the microbiome include new bile-acid conjugations [J].

Quinn, Robert A. ;

Melnik, Alexey, V ;

Vrbanac, Alison ;

Fu, Ting ;

Patras, Kathryn A. ;

Christy, Mitchell P. ;

Bodai, Zsolt ;

Belda-Ferre, Pedro ;

Tripathi, Anupriya ;

Chung, Lawton K. ;

Downes, Michael ;

Welch, Ryan D. ;

Quinn, Melissa ;

Humphrey, Greg ;

Panitchpakdi, Morgan ;

Weldon, Kelly C. ;

Aksenov, Alexander ;

da Silva, Ricardo ;

Avila-Pacheco, Julian ;

Clish, Clary ;

Bae, Sena ;

Mallick, Himel ;

Franzosa, Eric A. ;

Lloyd-Price, Jason ;

Bussell, Robert ;

Thron, Taren ;

Nelson, Andrew T. ;

Wang, Mingxun ;

Leszczynski, Eric ;

Vargas, Fernando ;

Gauglitz, Julia M. ;

Meehan, Michael J. ;

Gentry, Emily ;

Arthur, Timothy D. ;

Komor, Alexis C. ;

Poulsen, Orit ;

Boland, Brigid S. ;

Chang, John T. ;

Sandborn, William J. ;

Lim, Meerana ;

Garg, Neha ;

Lumeng, Julie C. ;

Xavier, Ramnik J. ;

Kazmierczak, Barbara, I ;

Jain, Ruchi ;

Egan, Marie ;

Rhee, Kyung E. ;

Ferguson, David ;

Raffatellu, Manuela ;

Vlamakis, Hera .

NATURE, 2020, 579 (7797) :123-+

[9]

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells [J].

Campbell, Clarissa ;

McKenney, Peter T. ;

Konstantinovsky, Daniel ;

Isaeva, Olga I. ;

Schizas, Michail ;

Verter, Jacob ;

Mai, Cheryl ;

Jin, Wen-Bing ;

Guo, Chun-Jun ;

Violante, Sara ;

Ramos, Ruben J. ;

Cross, Justin R. ;

Kadaveru, Krishna ;

Hambor, John ;

Rudensky, Alexander Y. .

NATURE, 2020, 581 (7809) :475-+

[10]

A metabolic pathway for bile acid dehydroxylation by the gut microbiome [J].

Funabashi, Masanori ;

Grove, Tyler L. ;

Wang, Min ;

Varma, Yug ;

McFadden, Molly E. ;

Brown, Laura C. ;

Guo, Chunjun ;

Higginbottom, Steven ;

Almo, Steven C. ;

Fischbach, Michael A. .

NATURE, 2020, 582 (7813) :566-+

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