特发性血小板减少性紫癜的细胞免疫异常研究新进展

被引：13

作者：

赵春红

侯明

机构：

[1] 山东大学齐鲁医院血液科

来源：

中国实验血液学杂志 | 2006年 / 05期

关键词：

特发性血小板减少性紫癜; T淋巴细胞; 细胞免疫;

D O I：

暂无

中图分类号：

R554.6 [];

学科分类号：

摘要：

长期以来认为特发性血小板减少性紫癜的病因主要是抗体介导的血小板破坏增多,但是体液免疫异常机制并不能解释发病中的所有现象。越来越多的研究表明细胞免疫异常参与了血小板破坏机制。本综述就T细胞耐受、T细胞凋亡异常、T细胞的异常激活、T细胞亚群及其功能改变、T细胞的细胞毒作用等作了概述。

引用

页码：1045 / 1048

页数：4

共 10 条

[1]

Effect of Protein Kinase C on Proliferation and Apoptosis of T Lymphocytes in Idiopathic Thrombocytopenic Purpura Children[J]. Changlin Wu~(1,2) Fang Liu~1 Xuemin Zhou~1 Zhengwei Cheng~1 Xiaomeng Yang~1 Hong Xiao~1 Qun Chen~1 Kangrong Cai~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong,524023,China;~2Corresponding to:Dr.Changlin Wu,Department of Microbiology and Immunology,Guangdong Medical College,2 Wen-Ming East Road,Zhanjiang,Guangdong,524023,China.

[2] CD4CD25T细胞在ITP发病中的作用 [J].

伏瑞祥 ;

吴德沛 .

现代免疫学, 2004, (01) :22-82

[3] 特发性血小板减少性紫癜患者外周血淋巴细胞协同刺激分子的表达 [J].

赵艳霞 ;

高清平 ;

陈友华 ;

敖绪斌 ;

陈伦华 ;

杨年兰 ;

王琼玉 ;

沈立云 .

中华血液学杂志, 2003, (09) :29-31

[4] Corticosteroid administration depresses circulating dendritic cells in ITP patients [J].

Hsu, NC ;

Chung, CY ;

Horng, HC ;

Chang, CS .

PLATELETS, 2004, 15 (07) :451-454

[5]

Dendritic cell-mediated T cell polarization[J] . Esther C. Jong,Hermelijn H. Smits,Martien L. Kapsenberg.Springer Seminars in Immunopathology . 2004 (3)

[6] Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias [J].

Shenoy, S ;

Mohanakumar, T ;

Chatila, T ;

Tersak, J ;

Duffy, B ;

Wang, R ;

Thilenius, ARB ;

Russell, JH .

CLINICAL IMMUNOLOGY, 2001, 99 (02) :266-275

[7] Functional properties of lymphocytes in idiopathic thrombocytopenic purpura [J].

Webber, NP ;

Mascarenhas, JO ;

Crow, MK ;

Bussel, J ;

Schattner, EJ .

HUMAN IMMUNOLOGY, 2001, 62 (12) :1346-1355

[8] A transforming growth factor-β1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura [J].

Andersson, PO ;

Stockelberg, D ;

Jacobsson, S ;

Wadenvik, H .

ANNALS OF HEMATOLOGY, 2000, 79 (09) :507-513

[9] Autoimmunity can benefit self-maintenance [J].

Schwartz, M ;

Cohen, IR .

IMMUNOLOGY TODAY, 2000, 21 (06) :265-268

[10]

Effects of Interferon-＆alpha;Therapy on Immune Parameters in Immune Thrombocytopenic Purpura[J] . A. R. Crossley,A. M. Dickinson,S. J. Proctor,J. E. Calvert.Autoimmunity . 1996 (2)

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