自噬在脑缺血中的双重作用

被引：10

作者：

王燕梅

徐恩

机构：

[1] 广州医学院第二附属医院神经科学研究所

来源：

国际脑血管病杂志 | 2012年 / 03期

关键词：

自噬; 脑缺血; 缺血预处理; 神经元; 细胞死亡; 细胞凋亡; 神经保护药;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

自噬是一种细胞内成分降解过程,分为启动、延伸、成熟以及自噬体降解等不同阶段,其作用与细胞损伤程度有关。自噬在饥饿、低氧等情况下适度激活,可促进细胞存活;而在脑缺血时过度激活,可导致细胞裂解和促进细胞死亡。预处理可能通过适当激活自噬而产生缺血耐受作用。自噬受到多种蛋白激酶、凋亡分子以及氧化应激通路的严格调控。

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