磷酸二酯酶-5抑制剂检测方法研究进展

被引：1

作者：

郭杰标 ^{[1
]}

许杨 ^{[1
,2
]}

机构：

[1] 南昌大学食品科学与技术国家重点实验室

[2] 南昌大学中德联合研究院

来源：

食品与生物技术学报 | 2010年 / 03期

关键词：

磷酸二酯酶-5; 抑制剂; 检测;

D O I：

暂无

中图分类号：

TQ460.7 [产品检验及分析鉴定];

学科分类号：

摘要：

3种获准上市的磷酸二酯酶-5抑制剂药物(西地那非、伐地那非和他达那非)在市场上获得了巨大成功。不法商人把这些药品违法添加到植物保健品和药品中谋取利益,对公众的健康构成了威胁。不断出现的PDE-5抑制剂的结构类似物导致问题变得更加复杂。目前,在标准品的参照下,TLC、HPLC、LC-MS和MECC等检测方法可以实现对已知PDE-5药物的检测。只有液相/离子阱串联质谱能够同时检测合法的药物和未知的PDE-5抑制剂类似物。免疫学检测方法正成为快速、灵敏、高效检测PDE-5药物的新方法。

引用

页码：331 / 335

页数：5

共 7 条

[1] A novel broad-specific noncompetitive immunoassay and its application in the determination of total aflatoxins [J].

Acharya, Debopam ;

Dhar, Tarun K. .

ANALYTICA CHIMICA ACTA, 2008, 630 (01) :82-90

[2] Quantitative detection of tetracycline residues in honey by a simple sensitive immunoassay [J].

Jeon, Moonsun ;

Paeng, Insook Rhee .

ANALYTICA CHIMICA ACTA, 2008, 626 (02) :180-185

[3]

Use of liquid chromatography–mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a “natural” herbal dietary supplement[J] . John C. Reepmeyer,Jeffrey T. Woodruff.Journal of Chromatography A . 2006 (1)

[4] Structure elucidation of sildenafil analogues in herbal products [J].

Blok-Tip, L ;

Zomer, B ;

Bakker, F ;

Hartog, KD ;

Hamzink, M ;

ten Hove, J ;

Vredenbregt, M ;

de Kaste, D .

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2004, 21 (08) :737-748

[5]

Simultaneous identification/determination system for phentolamine and sildenafil as adulterants in soft drinks advertising roborant nutrition[J] . Eiichi Mikami,Tsutomu Ohno,Hiroshi Matsumoto.Forensic Science International . 2002 (2)

[6]

Screening Methods for Drugs and Heavy Metals in Chinese Patent Medicines[J] . A. M. Au,R. Ko,F. O. Boo,R. Hsu,G. Perez,Z. Yang.Bulletin of Environmental Contamination and Toxicology . 2000 (1)

[7]

Simultaneousdetermination of synthetic phosphodiesterase-5 inhibitors found in adietary supplement and pre-mixed bulk powders for dietary supple-ments using high-performance liquid chromatography with diode ar-ray detection and liquid chromatography-electr. Zou Peng,Sharon Sze-Yin Oh,Hou Pei-ling,et al. Journal of Chromatography A . 2006

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