小剂量氯胺酮用于术后镇痛的研究及其临床价值

被引：147

作者：

刘国凯

黄宇光

罗爱伦

机构：

[1] 中国医学科学院中国协和医科大学北京协和医院麻醉科

来源：

中华麻醉学杂志 | 2003年 / 03期

关键词：

小剂量氯胺酮; 副作用; 术后疼痛; 硬膜外; 阿片类药物;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

<正> N-甲基-D-天冬氨酸受体(NMDA受体)的发现和它对疼痛过程及脊髓神经元可塑性变化的影响重新引起人们对氯胺酮(NMDA受体拮抗剂)作为潜在抗痛觉过敏药物的兴趣。现已清楚大剂量氯胺酮作为麻醉药物和小剂量作为镇痛药物或抗痛觉过敏作用之间的区别,小剂量氯胺酮其本身不产生镇痛作用,但是与阿片类药物联合应用时可减少阿片的用量,并比单独用药镇痛效果更好。本文总结了术后疼痛治疗中小剂量氯胺酮的不同给药方式的应用情况;并探讨了小剂量氯胺酮的副作用和未来研究的方向。小剂量氯胺酮的定义为一次肌注小于2 mg/kg,或者经静脉或硬膜外小于1 mg/kg,或者经静脉持续输注≤20μg·kg-1·min-1。

引用

页码：78 / 80

页数：3

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