半乳糖凝集素3在老年收缩功能正常心力衰竭患者中的临床价值

被引：24

作者：

施冰

冬兰

尹秋生

邵英

毕磊

张健

机构：

[1] 北京军区总医院干一科

来源：

中华老年心脑血管病杂志 | 2014年 / 16卷 / 01期

关键词：

半乳糖凝集素3; 心力衰竭; 利钠肽,脑; 超声心动描记术; 早期诊断;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

100201 [内科学];

摘要：

目的探讨老年心力衰竭(心衰)患者血浆半乳糖凝集素3(galectin-3)表达及其与心脏结构、功能的关系,为心衰的早期诊断和评估提供新的方法。方法选取老年患者106例,根据美国Framingham心衰诊断标准和纽约心功能(NYHA)分级标准分为心衰组55例和非心衰组51例,检测其血浆galectin-3和B型钠尿肽(BNP)表达,应用超声心动图评价心脏结构和功能。结果心衰组冠心病、心房颤动、陈旧性心肌梗死、左心房内径、左心室舒张末内径、galectin-3、BNP表达明显高于非心衰组,LVEF明显低于非心衰组,差异有统计学意义(P<0.01)。galectin-3与BNP(r=0.890,P<0.01)、左心房内径(r=0.966,P<0.01)、左心室舒张末内径(r=0.905,P<0.01)呈正相关。结论血浆galectin-3增高与心衰有关,galectin-3可能作为生物标记物帮助早期识别心衰。

引用

页码：12 / 14

页数：3

共 11 条

[1]

Biological variation of galectin-3 and soluble ST2 for chronic heart failure: Implication on interpretation of test results [J].

Wu, Alan H. B. ;

Wians, Frank ;

Jaffe, Allan .

AMERICAN HEART JOURNAL, 2013, 165 (06) :995-999

[2]

Incremental Prognostic Power of Novel Biomarkers (Growth-Differentiation Factor-15; High-Sensitivity C-Reactive Protein; Galectin-3; and High-Sensitivity Troponin-T) in Patients With Advanced Chronic Heart Failure.[J].Dirk J. Lok;IJsbrand T. Klip;Sjoukje I. Lok;Pieta W. Bruggink-André de la Porte;Erik Badings;Jan van Wijngaarden;Adriaan A. Voors;Rudolf A. de Boer;Dirk J. van Veldhuisen;Peter van der Meer.The American Journal of Cardiology.2013,

[3]

The fibrosis marker galectin‐3 and outcome in the general population.[J].R. A. de Boer;D. J. van Veldhuisen;R. T. Gansevoort;A. C. Muller Kobold;W. H. van Gilst;H. L. Hillege;S. J. L. Bakker;P. van der Harst.Journal of Internal Medicine.2011, 1

[4]

Cardiac biomarkers – the old and the new: a review.[J]..Coronary Artery Disease.2010, 4

[5]

Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study [J].

Lok, Dirk J. A. ;

Van Der Meer, Peter ;

Bruggink-Andre de la Porte, Pieta W. ;

Lipsic, Erik ;

Van Wijngaarden, Jan ;

Hillege, Hans L. ;

van Veldhuisen, Dirk J. .

CLINICAL RESEARCH IN CARDIOLOGY, 2010, 99 (05) :323-328

[6]

The relationship between serum galectin-3 and serum markers of cardiac extracellular matrix turnover in heart failure patients.[J].Yen-Hung Lin;Lian-Yu Lin;Yen-Wen Wu;Kuo-Liong Chien;Chi-Ming Lee;Ron-Bin Hsu;Chia-Lun Chao;Shoei-Shen Wang;Yenh-Chen Hsein;Lin-Chu Liao;Yi-Lwun Ho;Ming-Fong Chen.Clinica Chimica Acta.2009, 1

[7]

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography [J].

Nagueh, Sherif F. ;

Appleton, Christopher P. ;

Gillebert, Thierry C. ;

Marino, Paolo N. ;

Oh, Jae K. ;

Smiseth, Otto A. ;

Waggoner, Alan D. ;

Flachskampf, Frank A. ;

Pellikka, Patricia A. ;

Evangelista, Arturo .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2009, 22 (02) :107-133

[8]

Plasma biomarkers of myocardial fibrosis and remodeling in terminal heart failure patients supported by mechanical circulatory support devices [J].

Milting, Hendrik ;

Ellinghaus, Peter ;

Seewald, Michael ;

Cakar, Hamdin ;

Bohms, Birte ;

Kassner, Astrid ;

Koerfer, Reiner ;

Klein, Martina ;

Krahn, Thomas ;

Kruska, Lothar ;

El Banayosy, Aly ;

Kramer, Frank .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2008, 27 (06) :589-596

[9]

Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival [J].

Elola, M. T. ;

Wolfenstein-Todel, C. ;

Troncoso, M. F. ;

Vasta, G. R. ;

Rabinovich, G. A. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2007, 64 (13) :1679-1700

[10]

Expression and immunohistochemical localization of galectin-3 in various mouse tissues.[J].Heechul Kim;Jeeyoung Lee;Jin Won Hyun;Jae Woo Park;Hong-gu Joo;Taekyun Shin.Cell Biology International.2006, 7

← 1 2 →