PI3K/Akt/mTOR通路在炎症相关疾病中分子机制研究进展

被引：93

作者：

嵇莹莹

龚国清

机构：

[1] 中国药科大学药学院

来源：

药学研究 | 2018年 / 37卷 / 04期

关键词：

炎症; 信号通路; 磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白通路;

D O I：

10.13506/j.cnki.jpr.2018.04.011

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

炎症是一种机体应对感染、组织损伤或者细胞应激的反应,并且可以通过修复机制恢复组织功能。炎症发生时会引起多条信号通路的激活,包括核转录因子-κB(NF-κB)通路、Janus激酶/信号转导与转录激活子(JAK/STAT)通路、丝裂原活化蛋白激酶(MAPK)通路以及磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白(PI3K/Akt/mTOR)通路等。本文综述了近年来磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白通路在炎症相关疾病中的分子作用机制,为研发以磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白为靶点的药物提供理论依据。

引用

页码：226 / 229

页数：4

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