Nrf2/ARE信号通路与肝脏疾病的研究进展

被引：20

作者：

李春 ^{[1
,2
]}

邓晔 ^{[1
,2
]}

郭瑶雪 ^{[1
,2
]}

颜苗 ^{[1
]}

彭文兴 ^{[1
]}

机构：

[1] 中南大学湘雅二医院临床药学研究所

[2] 中南大学药学院

来源：

中国医院药学杂志 | 2015年 / 35卷 / 04期

关键词：

Nrf2; 肝脏疾病; 氧化应激;

D O I：

10.13286/j.cnki.chinhosppharmacyj.2015.04.23

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

对近几年关于Nrf2在各种肝脏疾病中作用的文献进行分析、归纳、总结,发现Nrf2/ARE信号通路的激活在防治病毒性肝炎、酒精性和非酒精性肝炎、胆汁淤积型肝损伤、肝纤维化、肝癌等肝脏疾病中起着重要作用。Nrf2/ARE通路在肝脏病理生理学过程中发挥重要作用,可能为防治肝脏疾病提供新的治疗靶点。

引用

页码：363 / 366

页数：4

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