基质金属蛋白酶与椎间盘退变研究的新进展

被引：26

作者：

綦惠 ^{[1
]}

赵丹慧 ^{[1
]}

田伟 ^{[1
,2
]}

机构：

[1] 北京市创伤骨科研究所

[2] 北京积水潭医院

来源：

中国脊柱脊髓杂志 | 2010年 / 20卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R681.5 [脊柱及背疾病];

学科分类号：

100220 [骨科学];

摘要：

<正>基质金属蛋白酶(matrix metalloproteinases,MMPs)是结构中含有金属离子Zn2+、Ca2+的蛋白水解酶,是分解细胞外基质(extracellularmatrix,ECM)的蛋白酶中最重要的一类,可以降解除多糖外几乎所有ECM成分。从40多年前

引用

页码：69 / 72

页数：4

共 20 条

[1]

Association between the-1562 C/T Polymorphism of Matrix Metalloproteinase-9 Gene and Lumbar Disc Disease in the Young Adult Population in North China [J].

Sun, Zheng-ming ;

Miao, Liu ;

Zhang, Yin-gang ;

Ming, Ling .

CONNECTIVE TISSUE RESEARCH, 2009, 50 (03) :181-185

[2]

Mechanism of Signal Transduction in Tumor Necrosis Factor-Like Weak Inducer of Apoptosis-Induced Matrix Degradation by MMP-3 Upregulation in Disc Tissues [J].

Wako, Masanori ;

Ohba, Tetsuro ;

Ando, Takashi ;

Arai, Yoshiyasu ;

Koyama, Kensuke ;

Hamada, Yoshiki ;

Nakao, Atsuhito ;

Haro, Hirotaka .

SPINE, 2008, 33 (23) :2489-2494

[3]

Future perspectives of cell-based therapy for intervertebral disc disease.[J].Daisuke Sakai.European Spine Journal.2008, 4

[4]

Gene therapy approach for disc degeneration and associated spinal disorders [J].

Kotaro Nishida ;

Teppei Suzuki ;

Kenichiro Kakutani ;

Takashi Yurube ;

Koichiro Maeno ;

Masahiro Kurosaka ;

Minoru Doita .

European Spine Journal, 2008, 17 :459-466

[5]

Pathophysiology of the human intervertebral disc [J].

Colombini, Alessandra ;

Lombardi, Giovanni ;

Corsi, Massimiliano Marco ;

Banfi, Giuseppe .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (05) :837-842

[6]

A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation [J].

Hirose, Yuichiro ;

Chiba, Kazuhiro ;

Karasugi, Tatsuki ;

Nakajima, Masahiro ;

Kawaguchi, Yoshiharu ;

Mikami, Yasuo ;

Furuichi, Tatsuya ;

Mio, Futoshi ;

Miyake, Atsushi ;

Miyamoto, Takeshi ;

Ozaki, Kouichi ;

Takahashi, Atsushi ;

Mizuta, Hiroshi ;

Kubo, Toshikazu ;

Kimura, Tomoatsu ;

Tanaka, Toshihiro ;

Toyama, Yoshiaki ;

Ikegawa, Shiro .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (05) :1122-1129

[7]

TNF-α induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration [J].

Seguin, Cheryle A. ;

Pilliar, Robert M. ;

Madri, Joseph A. ;

Kandel, Rita A. .

SPINE, 2008, 33 (04) :356-365

[8]

Genetic factors are associated with Modic changes in endplates of lumbar vertebral bodies [J].

Karppinen, Jaro ;

Daavittila, Iita ;

Solovieva, Svetlana ;

Kuisma, Mari ;

Taimela, Simo ;

Natri, Antero ;

Haapea, Marianne ;

Korpelainen, Raija ;

Niinimaeki, Jaakko ;

Tervonen, Osmo ;

Ala-Kokko, Leena ;

Maennikoe, Minna .

SPINE, 2008, 33 (11) :1236-1241

[9]

Plasmin-matrix metalloproteinase cascades in spinal response to an experimental disc lesion in pig [J].

Salo, Jari ;

Mackiewicz, Zygmunt ;

Indahl, Aage ;

Konttinen, Yrjoe T. ;

Holm, Allison Kaigle ;

Sukura, Antti ;

Holm, Sten .

SPINE, 2008, 33 (08) :839-844

[10]

Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels [J].

Rutges, J. P. H. J. ;

Kummer, J. A. ;

Oner, F. C. ;

Verbout, A. J. ;

Castelein, R. J. M. ;

Roestenburg, H. J. A. ;

Dhert, W. J. A. ;

Creemers, L. B. .

JOURNAL OF PATHOLOGY, 2008, 214 (04) :523-530

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