Toll样受体与心脏疾病

被引：6

作者：

杨晶

姜德建

张一帅

李元建

胡长平

机构：

[1] 中南大学药学院药理学系

来源：

中国药理学通报 | 2008年 / 09期

关键词：

Toll样受体; 先天性免疫; 心脏疾病;

D O I：

暂无

中图分类号：

R541 [心脏疾病];

学科分类号：

100201 [内科学];

摘要：

Toll样受体(Toll-like receptors,TLRs)是先天性免疫系统的重要受体,可识别不同的病原体,激活快速先天免疫反应。TLRs也可被宿主源性分子激活,不仅在免疫细胞表达,在内皮和心肌细胞也有高表达。大量研究表明,TLRs参与了心肌梗死、心力衰竭、心肌炎等心脏疾病的发生和发展,被认为是先天性免疫和心脏疾病之间的重要联系。TLRs可能是心脏疾病防治的新靶点。

引用

页码：1121 / 1123

页数：3

共 10 条

[1]

TLR signaling [J].

Kawai, Taro ;

Akira, Shizuo .

SEMINARS IN IMMUNOLOGY, 2007, 19 (01) :24-32

[2]

Inhibition of Toll-like Receptor 4 With Eritoran Attenuates Myocardial Ischemia-Reperfusion Injury.[J].Akira Shimamoto;Albert J. Chong;Masaki Yada;Shin Shomura;Hiroo Takayama;Ani J. Fleisig;Matthew L. Agnew;Craig R. Hampton;Christine L. Rothnie;Denise J. Spring;Timothy H. Pohlman;Hideto Shimpo;Edward D. Verrier.Circulation.2006, 1 su

[3]

Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[4]

Caught in the act:: In vivo molecular imaging of the transcription factor NF-κB after myocardial infarction [J].

Tillmanns, J ;

Carlsen, H ;

Blomhoff, R ;

Valen, G ;

Calvillo, L ;

Ertl, G ;

Bauersachs, J ;

Frantz, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 342 (03) :773-774

[5]

MyD88 signaling controls autoimmune myocarditis induction [J].

Marty, RR ;

Dirnhofer, S ;

Mauermann, N ;

Schweikert, S ;

Akira, S ;

Hunziker, L ;

Penninger, JM ;

Eriksson, U .

CIRCULATION, 2006, 113 (02) :258-265

[6]

Downregulation of Apoptosis-Inducing Factor in Harlequin Mutant Mice Sensitizes the Myocardium to Oxidative Stress–Related Cell Death and Pressure Overload–Induced Decompensation.[J].Vanessa P.M. van Empel;Anne T. Bertrand;Roel van der Nagel;Sawa Kostin;Pieter A. Doevendans;Harry J. Crijns;Elly de Wit;Wim Sluiter;Susan L. Ackerman;Leon J. De Windt.Circulation Research.2005, 12

[7]

Requirement of Nuclear Factor-κB in Angiotensin II– and Isoproterenol-Induced Cardiac Hypertrophy In Vivo.[J].Christian Freund;Ruth Schmidt-Ullrich;Anthony Baurand;Sandra Dunger;Wolfgang Schneider;Peter Loser;Amina El-Jamali;Rainer Dietz;Claus Scheidereit;Martin W. Bergmann.Circulation.2005, 18

[8]

Toll-Like Receptor 2 Mediates Staphylococcus aureus–Induced Myocardial Dysfunction and Cytokine Production in the Heart.[J].Pascal Knuefermann;Yasushi Sakata;J Scott Baker;Chien-Hua Huang;Kenichi Sekiguchi;Hordur S. Hardarson;Osamu Takeuchi;Shizuo Akira;Jesus G. Vallejo.Circulation.2004, 24

[9]

Immune cell toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia [J].

Tavener, SA ;

Long, EM ;

Robbins, SM ;

McRae, KM ;

Van Remmen, H ;

Kubes, P .

CIRCULATION RESEARCH, 2004, 95 (07) :700-707

[10]

Role of TLR4/MD-2 and RP105/MD-1 in innate recognition of lipopolysaccharide [J].

Kimoto, M ;

Nagasawa, K ;

Miyake, K .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2003, 35 (09) :568-572

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