血清尿酸水平与急性脑梗死患者脑血管损害的相关性分析

被引：11

作者：

郭建军

陈炽邦

魏伟民

李牧

钟建斌

机构：

[1] 增城市人民医院神经内科

来源：

临床和实验医学杂志 | 2010年 / 9卷 / 03期

关键词：

尿酸; 脑梗死; 大动脉粥样硬型; 小动脉闭塞型;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）]; R589.7 [嘌呤（Purine）代谢障碍];

学科分类号：

摘要：

目的探讨血清尿酸水平与急性脑梗死患者脑血管损害的相关性。方法选取大动脉粥样硬化(LAA)型和小动脉闭塞(SAO)型急性脑梗死住院患者371例,记录临床危险因素、实验室检查指标,进行统计分析。结果男性、高血压病、高三酰甘油(TG)血症、低高密度脂蛋白胆固醇(HDL-C)血症及血糖升高患者血清尿酸水平较高(P<0.05)。与SAO型相比,LAA型脑梗死患者血清尿酸水平较高,而TG及HDL-C水平较低(P<0.05)。Logistic回归分析结果显明,尿酸水平升高和TG水平降低是发生大血管损害的重要危险因素。结论高尿酸血症患者易发生LAA型脑梗死,而高三酰甘油血症患者易发生SAO型脑梗死。

引用

页码：167 / 168+172 +172

页数：3

共 9 条

[1]

Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. Kang DH,Park SK,Lee IK,et al. Journal of the American Society of Nephrology . 2005

[2]

Hyperuricemia induces endothelial dysfunction. Khosla UM,Zharikov S,Finch JL,et al. Kidney International . 2005

[3]

Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Weir CJ,Muir SW,Walters MR,et al. Stroke . 2003

[4]

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase- mediated oxidative/nitrosative stress. Sautin YY,Nakagawa T,Zharikov S,et al. American Journal of Physiology Cell Physiology . 2007

[5]

A causal role.for uric acid in.fructose-induced metabolic syndrome. Nakagawa,T.et al. American Journal of Physiology Renal Physiology . 2006

[6]

Hyperuricemia and risk of stroke:A sy-stematic review and meta-analysis. Kim SY,Guevara JP,Kim KM,et al. Arthritis and Rheumatism . 2009

[7] 高尿酸血症与脑血管病 [J].

陈登青 ;

徐恩 .

国外医学(脑血管疾病分册), 2005, (02) :144-146

[8]

Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions[J] . Mehmet Kanbay,Adem Ozkara,Yusuf Selcoki,Bunyamin Isik,Faruk Turgut,Nuket Bavbek,Ebru Uz,Ali Akcay,Ramazan Yigitoglu,Adrian Covic. &nbspInternational Urology and Nephrology . 2007 (4)

[9]

Classification of subtype of acute ischemic stroke. Adams H P,Bendixen B H,Kapelle L J,et al. Stroke . 1993

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