血管紧张素Ⅱ受体拮抗剂在心血管疾病中的应用进展

被引:11
作者
张继雁
邵忠
机构
[1] 山东省曹县人民医院!
关键词
洛沙坦; 卡托普利; ATI; 心血管疾病; 受体;
D O I
暂无
中图分类号
R540.5 [];
学科分类号
1002 ; 100201 ;
摘要
<正>肾素-血管紧张素系统(RAS)是体内调节血压和水电解质平衡的主要系统,该系统通过一系列酶促反应,最后通过血管紧张素Ⅱ(AngⅡ)发挥作用。至今RAS的各种阻滞剂广泛应用于高血压和充血性心力衰竭的治疗和研究中,第一类是熟知的血管紧张素转换酶抑制剂(ACEI),第二类是即将推向临床的竞争性AngⅡ受体的拮抗剂,第三类是正在研究中的选择性肾素抑制剂。新型的AngⅡ受体拮抗剂从受体水平阻断AngⅡ的作用,理论上讲,这类药物更特异、更有效地阻断RAS,因而对它们的研究日益受到关注。
引用
收藏
页码:378 / 379
页数:2
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